白血病抑制因子受体在心肌梗死患者血液中的表达水平及其临床意义  

Serum LIFR level and its clinical significance in myocardial infarction patients

作　　者：邓江洋 郭莹莹 冯一州 夏红霞[1] 王梦婷 袁园 Deng Jiangyang;Guo Yingying;Feng Yizhou;Xia Hongxia;Wang Mengting;Yuan Yuan(Department of Cardiology:Hubei Provincial Key Laboratory of Metabolism and Related Chronic Diseases,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China)

机构地区：[1]武汉大学人民医院心血管内科、代谢与相关慢病湖北省重点实验室,430060

出　　处：《中华老年心脑血管病杂志》2025年第4期459-462,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(82300270)。

摘　　要：目的探讨白血病抑制因子受体(leukemia inhibitory factor receptor,LIFR)在非ST段抬高型心肌梗死(non-ST-segment elevation myocardial infarction,NSTEMI)患者中的表达情况及其与心肌重构的可能关联。方法前瞻性选取2023年1月至2024年11月于武汉大学人民医院行冠状动脉造影的急性心肌梗死患者188例,根据是否诊断为NSTEMI分为对照组94例和NSTEMI组94例。收集患者一般临床资料,采用线性回归分析LIFR及与其他指标的相关性。结果与对照组比较,NSTEMI组吸烟史、LIFR、N末端B型钠尿肽前体、肌钙蛋白I、肌酐、尿酸、白细胞计数显著升高,左心室射血分数显著降低,差异有统计学意义[48.94%vs 13.83%,P<0.01;5.82(4.23,8.11)mmol/L vs 0.97(0.60,1.41)mmol/L,P<0.01;2.53(1.24,9.71)pg/L vs 0.03(0.02,0.04),P<0.01;18.57(4.11,250.00)ng/L vs 0.00(0.00,0.00)ng/L,P<0.01;82.50(68.00,121.25)μmol/L vs 68.50(53.00,88.25)μmol/L,P<0.01;411.00(349.00,521.25)μmol/L vs 337.00(286.75,406.00)μmol/L,P<0.01;10.21(8.71,13.09)×10~9/L vs 6.22(4.67,7.46)×10~9/L,P<0.01;47.00(38.00,54.00)%vs 59.00(56.00,60.00)%,P<0.01]。心肌梗死患者血清LIFR与N末端B型钠尿肽前体、肌钙蛋白I及白细胞计数呈正相关(β=1.403,95%CI:10597.867~17327.087,P=0.000;β=0.232,95%CI:114.558~1769.808,P=0.026;β=0.336,95%CI:0.164~0.617,P=0.001)。结论LIFR可能通过炎症参与心肌梗死后心肌重构和心力衰竭的发展。Objective To explore the expression of leukemia inhibitory factor receptor(LIFR)in patients with non-ST-segment elevation myocardial infarction(NSTEMI)and its possible association with myocardial remodeling.Methods A total of 188 patients with acute myocardial infarction who underwent coronary angiography in our hospital from January 2023 to November 2024 were prospectively enrolled and divided into a control group(94 cases)and an NSTEMI group(94 cases)according to being diagnosed with NSTEMI or not.General clinical data of the patients were collected,and the correlation between serum LIFR level and other indicators was analyzed using linear regression analysis.Results Compared with the control group,the NSTEMI group had significantly higher ratios of smoking history,elevated levels of LIFR,NT-proBNP,cTnI,Cr and UA,increased WBC count,but lower LVEF value[48.94%vs 13.83%,P<0.01;5.82(4.23,8.11)mmol/L vs 0.97(0.60,1.41)mmol/L,P<0.01;2.53(1.24,9.71)pg/L vs 0.03(0.02,0.04),P<0.01;18.57(4.11,250.00)ng/L vs 0.00(0.00,0.00)ng/L,P<0.01;82.50(68.00,121.25)μmol/L vs 68.50(53.00,88.25)μmol/L,P<0.01;411.00(349.00,521.25)μmol/L vs 337.00(286.75,406.00)μmol/L,P<0.01;10.21(8.71,13.09)×10~9/L vs 6.22(4.67,7.46)×10~9/L,P<0.01;47.00(38.00,54.00)%vs 59.00(56.00,60.00)%,P<0.01].Serum LIFR level in the patients was positively correlated with NT-proBNP,cTnI,Cr and WBC count(β=1.403,95%CI:10597.867-17327.087,P=0.000;β=0.232,95%CI:114.558-1769.808,P=0.026;β=0.336,95%CI:0.164-0.617,P=0.001).Conclusion LIFR may be involved in the development of myocardial remodeling and heart failure after myocardial infarction through its role in inflammation.

关 键 词：受体 OSM-LIF 心肌梗死 心室重构 心力衰竭 

分 类 号：R54[医药卫生—心血管疾病]