氢气吸入辅助治疗促进老年脑出血患者术后神经功能恢复  

Adjuvant hydrogen inhalation therapy facilitates postoperative neurological function in elderly patients with cerebral hemorrhage

作　　者：李岩 王胜军 冯钰珉 甄文剑 郝进敏 Li Yan;Wang Shengjun;Feng Yumin;Zhen Wenjian;Hao Jinmin(Second Ward of Neurosurgery Department,Xingtai Central Hospital,Xingtai 054000,Hebei Province,China)

机构地区：[1]邢台市中心医院神经外科二病区,054000

出　　处：《中华老年心脑血管病杂志》2025年第4期493-496,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：邢台市重点研发计划自筹项目(2021ZC097)。

摘　　要：目的探讨氢气吸入辅助治疗对老年脑出血患者术后神经功能恢复的影响。方法选取2021年1月至2023年2月邢台市中心医院神经外科接受手术治疗的脑出血患者100例,随机分为观察组(氢气吸入辅助治疗)和对照组(常规治疗),每组50例。比较2组格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、36项简明健康调查问卷(short from 36-item questionnaire,SF-36)评分和血清脑源性神经营养因子(brain derived neurotrophic facor,BDNF)、胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)、降钙素基因相关肽(calcitonin gene related peptide,CGRP)水平及并发症发生率。结果观察组治疗后4周及8周GCS评分、SF-36评分明显高于对照组,NIHSS评分明显低于对照组,差异有统计学意义(P<0.01)。观察组治疗后8周血清BDNF、IGF-1及CGRP水平明显高于对照组,差异有统计学意义(P<0.01)。2组并发症发生率比较,差异无统计学意义(6.00%vs 10.00%,P>0.05)。结论氢气吸入辅助治疗能够明显改善脑出血患者神经功能恢复和生活质量,提高血清神经功能指标水平。Objective To explore the effect of adjuvant hydrogen inhalation therapy(AHIT)on postoperative neurological recovery in elderly patients with cerebral hemorrhage.Methods A prospective study was conducted on 100 patients with cerebral hemorrhage who underwent surgical treatment in our department between January 2021 and February 2023.They were randomly divided into an observation group(AHIT)and a control group(conventional treatment),with 50 patients in each group.Glasgow Coma Scale(GCS)score,NIHSS score,short from 36-item questionnaire(SF-36)score,as well as levels of serum brain-derived neurotrophic factor(BDNF),insulin-like growth factor 1(IGF-1)and calcitonin gene-related peptide(CGRP),and incidence of complications were compared between the two groups.Results The observation group obtained significantly higher GCS score and SF-36 scores at 4 and 8 weeks after treatment,and lower NIHSS score when compared with the control group(P<0.01).At 8 weeks after treatment,the serum BDNF,IGF-1 and CGRP levels were notably higher in the observation group than the control group(P<0.01).There was no statistical difference in the incidence of complications between the two groups(6.00%vs 10.00%,P>0.05).Conclusion AHIT can significantly improve the neurological recovery and quality of life of patients with cerebral hemorrhage,as well as elevate the levels of serum neurofunctional markers.

关 键 词：脑出血 治疗 生活质量 认知障碍 

分 类 号：R74[医药卫生—神经病学与精神病学]