血液透析患者手指血钾微流体技术检测法的建立  

Establishment of microfluidic technology for detecting potassium in finger blood of hemodialysis patients

作　　者：刘键 谭志广 郝文联 张晓娜 王建雄 徐宏娟 彭丽敏 于海霞[2] 李晨曦[2] Jian Liu;Zhiguang Tan;Wenlian Hao;Xiaona Zhang;Jianxiong Wang;Hongjuan Xu;Limin Peng;Haixia Yu;Chenxi Li(Renal Ward of General Internal Medicine,Tianjin Rehabilitation and Recuperation Center of Joint Logistics Support Force,Tianjin 300381;Laboratory of Bioinformation Measurement and Biomanufacturing,School of Precision Instrument and Opto-electronics Engineering,Tianjin University,Tianjin 300072,China)

机构地区：[1]联勤保障部队天津康复疗养中心综合内科肾脏病区,300381 [2]天津大学精密仪器与光电子工程学院生物信息测量与生物制造实验室,300072

出　　处：《中华肾病研究电子杂志》2025年第1期13-17,共5页Chinese Journal of Kidney Disease Investigation(Electronic Edition)

摘　　要：目的探讨建立血液透析患者手指血钾微流体技术检测法的可行性。方法招募18例血液透析患者,每人采集手指血100μl通过微流体技术检测血钾,静脉血2 ml送检验科检测血钾。分析两种方式测得血钾浓度的差值和相关性。绘制受试者工作特征(ROC)曲线,以分析手指血钾>5.0 mmol/L对透析患者的诊治价值。结果微流体技术检测手指血钾浓度与检验科测得静脉血钾浓度相差约10%左右(r=0.774,P<0.05)。以手指血钾>5.0 mmol/L作为指标的ROC曲线下面积为0.938。结论微流体技术检测的手指血钾浓度与检验科检测的静脉血钾浓度成线性关系。基于微流体技术的手指血钾检测法,可能对于监测透析患者的血钾浓度具有一定价值。Objective To explore the feasibility of establishing a microfluidic technology for detecting potassium in finger blood of hemodialysis patients.Methods Eighteen hemodialysis patients were enrolled,from each of whom 100μl of finger blood was collected for potassium detection using the microfluidic technology,and 2 ml of venous blood was sent to the laboratory for potassium detection.The difference and correlation between the blood potassium concentrations measured by the two methods were analyzed.The receiver operating characteristic(ROC)curves were drawn to analyze the diagnostic and therapeutic value of finger blood potassium>5.0 mmol/L for dialysis patients.Results The difference between the finger blood potassium concentration detected by microfluidic technology and the venous blood potassium concentration measured by the laboratory was about 10%(r=0.774,P<0.05).The area under the ROC curve with the finger blood potassium>5.0 mmol/L being the indicator was 0.938.Conclusion The finger blood potassium concentration detected by microfluidic technology was linearly correlated to the venous blood potassium concentration detected by the laboratory.The finger blood potassium detection method based on microfluidic technology may have certain value for monitoring the blood potassium concentration of dialysis patients.

关 键 词：血钾 手指血 血液透析 监测 

分 类 号：R28[医药卫生—中药学]