基于数据挖掘探讨中药复方专利治疗痛风的用药规律  

Medication Rules of Traditional Chinese Medicine Compound Patent in the Treatment of Gout Based on Data Mining

作　　者：刘江腾 阮智超 张华[1] 潘星如 林元媛 赵进喜[1] LIU Jiangteng;RUAN Zhichao;ZHANG Hua;PAN Xingru;LIN Yuanyuan;ZHAO Jinxi(Dept.of Nephroendocrinology,Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院肾病内分泌科,北京100700

出　　处：《中国医院用药评价与分析》2025年第3期274-278,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家中医药管理局高水平中医药重点学科建设项目(No.zyyzdxk-2023255)。

摘　　要：目的:基于数据挖掘技术对治疗痛风的中药复方专利进行分析,探讨其用药配伍特点及组方规律。方法:检索1985年9月10日至2024年3月1日中国专利数据库中治疗痛风的中药复方专利,运用古今医案云平台(V2.3.7)、SPSS Statistics 26.0软件对符合纳入标准的中药复方专利进行药物频次和性味归经统计、关联规则分析、系统聚类分析和复杂网络分析。结果:共纳入中药复方558首,涉及中药383味。高频药物依次为牛膝、黄柏、甘草、苍术、薏苡仁和土茯苓等;药性以温性最多,其次为平性、寒性等;药味以甘味最多,其次为苦味、辛味等;归经以肝经最多,其次为脾经、肾经等;关联规则分析以苍术-黄柏药对的支持度和置信度最高,药物组合以牛膝为核心药物;聚类分析获得的药物组合有“黄柏、苍术、牛膝、薏苡仁、土茯苓、萆薢、防己、茯苓、秦艽、泽泻”等;复杂网络分析得到核心药物组成为苍术、黄柏、薏苡仁、牛膝、萆薢、土茯苓、威灵仙、当归、赤芍和甘草。结论:中药复方专利治疗痛风注重“湿热瘀毒”的基本病机,以清热化湿、活血解毒为基本治法,可配合祛风除湿、化瘀通络、健脾益气、补益肝肾等法,强调脾、肾、肝同调,常用四妙散、五苓散、黄芪赤风汤及补阳还五汤等方化裁,可为痛风的临床治疗及新药研发拓展思路。OBJECTIVE:To analyze the traditional Chinese medicine compound patent in the treatment of gout based on data mining,and explore the medication compatibility characteristics and formula rules.METHODS:Traditional Chinese medicine compound patent formulas in the treatment of gout from the Chinese Patent Database were retrieved from Sept.10th,1985 to Mar.1st,2024.The Ancient and Modern Medical Case Cloud Platform(V2.3.7)and SPSS Statistics 26.0 software were used to perform drug frequency and flavor meridian analysis,association rule analysis,systematic clustering analysis,and complex network analysis on the traditional Chinese medicine compound patent that meet the inclusion criteria.RESULTS:A total of 558 traditional Chinese medicine compound formulas were enrolled,including 383 traditional Chinese medicines.The high-frequency drugs were respectively Achyranthis bidentatae radix,Phellodendri chinrnsis cortex,licorice,Atractylodes lancea,Coicis semen and Smilacis glabrae rhixoma.The most common medicinal properties were warm,followed by mild and cold.The most common medicinal flavor was sweet,followed by bitter and spicy.The most common meridian was the liver meridian,followed by the spleen meridian,and kidney meridian.The association rule analysis showed that the combination of Atractylodes lancea-Phellodendri chinrnsis cortex had the highest support and confidence,with Achyranthis bidentatae radix as the core drug.The drug combination obtained from cluster analysis included Phellodendri chinrnsis cortex,Atractylodes lancea,Achyranthis bidentatae radix,Coicis semen,Smilacis glabrae rhixoma,Dioscorea hypoglauca,Stephaniae tetrandrae radix,Poria cocos,Gentiana Macrophylla Pall,and Alisma Orientale.Complex network analysis revealed the core drug composition Atractylodes lancea,Phellodendri chinrnsis cortex,Coicis semen,Chyranthis bidentatae radix,Dioscorea hypoglauca,Smilacis Glabrae Rhixoma,Radix Clematidis,Angelicae Sinensis Radix,Radix Paeoniae Rubra and licorice.CONCLUSIONS:Traditional Chinese medicine compound pa

关 键 词：痛风 中药复方专利 古今医案云平台 用药规律 

分 类 号：R932[医药卫生—生药学] R971.1[医药卫生—药学]