新疆地区双相情感障碍患者丙戊酸钠血药浓度的影响因素及效果分析  

Influencing Factors of Blood Concentration and Efficacy of Sodium Valproate in Patients with Bipolar Affective Disorder in Xinjiang

作　　者：吴宛焰 冯杰[1,2] 张惠兰 李红健 于鲁海[1,2] WU Wanyan;FENG Jie;ZHANG Huilan;LI Hongjian;YU Luhai(Dept.of Pharmacy,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China;Institute of Clinical Pharmacy of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院药学部,乌鲁木齐830001 [2]新疆维吾尔自治区临床药学研究所,乌鲁木齐830001

出　　处：《中国医院用药评价与分析》2025年第3期294-296,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：新疆维吾尔自治区自然科学基金资助项目(No.2023D01C69)。

摘　　要：目的:探讨新疆地区双相情感障碍患者丙戊酸钠血药浓度的影响因素及该药的临床疗效,以期为临床个体化用药提供参考。方法:回顾性收集2019年1月至2024年7月于该院接受丙戊酸钠治疗的双相情感障碍患者的临床资料,分析年龄、性别、民族、联合用药等因素对血药浓度的影响,观察患者的临床疗效。结果:共纳入118例患者,丙戊酸钠血药浓度为(46.60±25.85)mg/L,达标47例,达标率为39.83%。未成年患者的血药浓度显著高于成年患者,差异有统计学意义(P<0.05);患者性别、民族、联合用药与血药浓度均无相关性(P>0.05)。118例患者治疗后(出院时)的汉密尔顿抑郁评分、焦虑评分均较治疗前(入院时)显著降低,差异均有统计学意义(P<0.05)。结论:临床在应用丙戊酸钠治疗双相情感障碍患者时,有必要对丙戊酸钠的血药浓度进行监测,及时调整给药剂量,以提高临床疗效。OBJECTIVE:To probe into the influencing factors of blood concentration and clinical efficacy of sodium valproate in patients with bipolar affective disorder in Xinjiang,so as to provide references for clinical individualized medication.METHODS:Clinical data of patients with bipolar affective disorder who received sodium valproate in the hospital from Jan.2019 to Jul.2024 were retrospectively collected and analyzed in terms of the effects of age,gender,ethnicity and drug combination on blood concentration,the clinical efficacy were observed.RESULTS:A total of 118 patients were enrolled,the blood concentration of sodium valproate was(46.60±25.85)mg/L,47 cases met the standard,with the compliance rate of 39.83%.The blood concentration of sodium valproate was significantly higher in underage patients than that in adult patients,with statistically significant difference(P<0.05),there was no correlation between patient’s gender,ethnicity,drug combination and blood concentration(P>0.05).The scores of Hamilton Depression Scale and the Hamilton Anxiety Scale of the 118 patients were significantly lower after treatment(at the time of discharge)than those before treatment(at the time of admission),with statistically significant differences(P<0.05).CONCLUSIONS:In clinical practice of sodium valproate in the treatment of bipolar affective disorder,it is necessary to monitor the blood concentration of sodium valproate and adjust the dosage in a timely manner to improve clinical efficacy.

关 键 词：新疆 双相情感障碍 丙戊酸钠 血药浓度 

分 类 号：R971.43[医药卫生—药品]