基于德尔菲专家咨询调查法构建比阿培南的药物利用评价标准及应用  

Construction of Drug Utilization Evaluation Criteria for Biapenem Based on the Delphi Expert Consultation Survey Method and Its Application

作　　者：丁亮 孙盼丽 刘兵 DING Liang;SUN Panli;LIU Bing(Dept.of Pharmacy,Chang’an Hospital,Xi’an 710018,China;Dept.of Pharmacy,the First People’s Hospital of Xianyang,Shaanxi Xianyang 712099,China)

机构地区：[1]长安医院药剂科,西安710018 [2]咸阳市第一人民医院药剂科,陕西咸阳712099

出　　处：《中国医院用药评价与分析》2025年第3期343-345,351,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：陕西省教育厅专项科研计划项目(No.21JK0421)。

摘　　要：目的:通过病例资料的回顾性分析,建立长安医院(以下简称“该院”)比阿培南的药物利用评价(DUE)标准,使用德尔菲专家咨询调查法进行分析、评价,为临床合理使用亚胺培南提供参考。方法:对2022年7月至2023年12月该院使用比阿培南治疗的168例患者的临床资料进行回顾性分析,以比阿培南的药品说明书等资料为参考,结合相关专家意见,建立比阿培南的DUE标准,并评价比阿培南的应用合理性。结果:根据药品说明书、相关指南、共识及相关条例,对该院168例应用比阿培南治疗的患者用药医嘱进行评价,用药指征、用药过程和用药结果3个维度的符合标准率分别为92.86%(156/168)、74.40%(125/168)和71.43%(120/168)。比阿培南的DUE标准二级评价中,适应证、禁忌证、给药方式、给药剂量、药物相互作用的符合目标率较高,均>90%;特殊人群,给药时机,疗程,药物监测,不良反应,症状、体征及实验室检查方面的符合目标率较低,<90%。结论:该院比阿培南的用药不合理率较高,存在特殊人群用药、给药时机、疗程、药物监测等方面不合理的情况。通过建立DUE标准,可对比阿培南的临床应用情况进行科学、合理评价,以促进临床合理用药,提升用药安全性。OBJECTIVE:To establish the drug utilization evaluation(DUE)criteria of biapenem in Chang’an Hospital(hereinafter referred to as“the hospital”)based on retrospective analysis of case data,analyze and evaluate the DUE criteria by Delphi expert consultation survey method,so as to provide reference for rational use of imipenem in the clinic.METHODS:Clinical data of 168 patients treated with biapenem in the hospital from Jul.2022 to Dec.2023 were retrospectively analyzed.The DUE criteria of biapenem was constructed based on the drug instructions of biapenem and related expert opinions,and the application rationality of biapenem were evaluated.RESULTS:According to drug instructions,relevant guidelines,consensus and relevant regulations,168 patients treated with biapenem were evaluated.The results showed that the compliance rates of medication indication,medication process and medication result were 92.86%(156/168),74.40%(125/168)and 71.43%(120/168),respectively.In the DUE secondary evaluation of biapenem,the target compliance rate of indications,contraindications,administration method,administration dose and drug interaction was higher than 90%,while the target compliance rate of special population,administration timing,course of treatment,drug monitoring,adverse drug reactions,symptoms and signs,and laboratory examination was lower than 90%.CONCLUSIONS:The irrational rate of biapenem in the hospital is relatively high,and there are irrationality in drug use,administration timing,course of treatment and drug monitoring for special populations.Through the construction of DUE criteria,the clinical application of biapenem can be evaluated scientifically and reasonably,so as to promote the rational use of drugs in the clinic and improve the safety of drug use.

关 键 词：比阿培南 德尔菲专家咨询调查法 药物利用评价 合理用药 

分 类 号：R978.1[医药卫生—药品]