血清可溶性髓系细胞触发受体1、磷脂酶A2及国家早期预警评分对重症肺炎所致呼吸窘迫综合征患者预后的评估价值  

Prognostic value of serum soluble myeloid cell trigger receptor 1,phospholipase A2 and NEWS score in ARDS patients with severe pneumonia

作　　者：吴秀娟[1] 韩娜[1] 菅辉玲 马宏鹰 张大军[2] WU Xiujuan;HAN Na;KAN Huiling;MA Hongying;ZHANG Dajun(Department of Clinical Laboratory,Karamay Central Hospital,Karamay 834000,China;Health Management Center,Karamay Central Hospital,Karamay 834000,China)

机构地区：[1]克拉玛依市中心医院检验科,新疆克拉玛依834000 [2]克拉玛依市中心医院健康管理中心,新疆克拉玛依834000

出　　处：《陕西医学杂志》2025年第4期550-554,共5页Shaanxi Medical Journal

基　　金：新疆维吾尔自治区重点研发项目(2023GHD-1058)。

摘　　要：目的:探讨血清可溶性髓系细胞触发受体1(sTREM-1)、磷脂酶A2(PLA2)及国家早期预警评分(NEWS)对重症肺炎(SP)所致急性呼吸窘迫综合征(ARDS)患者预后的评估价值。方法:选取SP所致ARDS患者143例为ARDS组,另选64例同期健康体检者为对照组。比较对照组和ARDS组患者的血清sTREM-1、PLA2水平和NEWS评分,对SP所致ARDS患者预后不良的危险因素进行多因素Logistic回归分析。结果:与对照组比较,ARDS组患者血清sTREM-1、PLA2水平、NEWS评分出现显著升高(均P<0.05)。两组年龄、性别、吸烟史、饮酒史、高血压史、冠心病史、糖尿病史、高脂血症、舒张压、收缩压之间比较无统计学差异(均P>0.05),预后不良组患者机械通气时间明显较长(P<0.05),血清sTREM-1、PLA2水平、NEWS评分明显升高(均P<0.05)。机械通气时间长、高血清sTREM-1、PLA2水平、高NEWS评分是PSUI发生的危险因素(均P<0.05)。血清sTREM-1、PLA2联合NEWS评分对SP所致ARDS患者预后的评估价值明显高于三者独立检测(均P<0.05)。结论:SP所致ARDS患者预后不良的危险因素包括机械通气时间长、高血清sTREM-1、PLA2水平、高NEWS评分。血清sTREM-1、PLA2联合NEWS评分对SP所致ARDS患者预后具有较高的评估价值。Objective:Objective To evaluate the prognostic value of serum soluble myeloid cell trigger receptor 1(sTREM-1),phospholipase A2(PLA2)and national early warning(NEWS)scores in patients with acute respiratory distress syndrome(ARDS)caused by severe pneumonia(SP).Methods:A total of 143 patients with ARDS caused by SP were selected as ARDS group and 64 healthy subjects were selected as control group.The levels of serum sTREM-1,PLA2 and NEWS scores of ARDS patients in control group and ARDS group were compared,and the risk factors of poor prognosis of ARDS patients with SP were analyzed by multivariate Logistic regression.Results:Compared with control group,serum levels of sTREM-1,PLA2 and NEWS score in ARDS group were significantly increased(all P<0.05).There were no significant differences between the two groups in age,gender,smoking history,drinking history,hypertension history,coronary heart disease history,diabetes history,hyperlipidemia,diastolic blood pressure and systolic blood pressure(all P>0.05),and the mechanical ventilation time of patients with poor prognosis was significantly longer(P<0.05).Serum levels of sTREM-1,PLA2 and NEWS scores were significantly increased(all P<0.05).Long mechanical ventilation time,high serum sTREM-1,PLA2 levels and high NEWS score were the risk factors for PSUI(all P<0.05).Serum sTREM-1 and PLA2 combined NEWS scores were significantly higher in evaluating the prognosis of ARDS patients with SP than the three independent tests(all P<0.05).Conclusion:Serum sTREM-1 and PLA2 combined NEWS scores have high prognostic value in ARDS patients with SP,and are worthy of clinical promotion and use.

关 键 词：重症肺炎 急性呼吸窘迫综合征 可溶性髓系细胞触发受体1 磷脂酶A2 国家早期预警评分 预后 

分 类 号：R563.1[医药卫生—呼吸系统]