吉雷开窍汤联合西药治疗对胆腑郁热型慢性鼻窦炎患儿鼻腔菌群和鼻腔功能的影响  

Effect of Jilei Kaiqiao decoction combined with western medicine treatment on nasal flora and nasal function in patients with bile-vessel depression-heat type chronic sinusitis

作　　者：张竞飞[1] 俞鹏飞 安月鹏[1] 周凌[1] ZHANG Jingfei;YU Pengfei;AN Yuepeng;ZHOU Ling(The First Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《陕西中医》2025年第4期472-475,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81874495);国家中医药管理局第七批全国老中医药专家学术经验继承项目[国中医药人教函(2022)76号];黑龙江省卫健委科研课题(20220707011078);黑龙江省中医药学会青年人才托举工程项目(2022-QNRC1-19)。

摘　　要：目的:观察吉雷开窍汤联合西药治疗对胆腑郁热型慢性鼻窦炎(CRS)患儿鼻腔菌群和鼻腔功能的影响。方法:选取72例胆腑郁热型CRS患儿,采用随机数字表法分为试验组和常规组。常规组给予常规西药治疗,试验组使用吉雷开窍汤联合西药治疗。记录两组临床疗效、鼻腔鼻窦结局测试-20(SNOT-20)量表评分,并检测两组鼻腔菌群、鼻腔功能以及血清相关因子[肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、γ干扰素(IFN-γ)]水平。结果:两组治疗后SNOT-20评分、鼻腔菌群、鼻腔功能和IL-6、TNF-α明显低于治疗前,且试验组患儿低于常规组(均P<0.05);治疗后试验组IFN-γ水平高于治疗前(P<0.05)。结论:吉雷开窍汤联合西药治疗能有效改善胆腑郁热型CRS患儿症状,降低多项鼻腔菌群数量,有效恢复鼻腔功能。Objective:To observe the effects of Jilei Kaiqiao decoction combined with western medicine on the nasal flora and nasal function of child patients with bile-vessel depression-heat type chronic sinusitis(CRS).Methods:Seventy-two pediatric patients with cholestasis-type CRS were selected and divided into the experimental group and the conventional group using the randomized numeric table method.The conventional group was given conventional western medicine treatment,and the experimental group was treated with Jilei Kaiqiao decoction combined with western medicine.The clinical efficacy and SNOT-20 scale before and after treatment were recorded,and the changes in nasal flora and nasal function before and after treatment were detected,as well as the serum-related factors[tumor necrosis factor-α(TNF-α),interleukin 6(IL-6),and interferon gamma(IFN-γ)]levels.Results:After treatment,SNOT-20 score,nasal flora,nasal function,IL-6 and TNF-α were significantly lower in both groups than before treatment,and experimental group was lower than conventional group(all P<0.05).The level of IFN-γ in experimental group after treatment was higher than that before treatment(P<0.05).Conclusion:Jilei Kaiqiao decoction combined with western medicine treatment can effectively improve the condition and symptoms of children with bile-vessel depression-heat type CRS,reduce the number of nasal flora,and effectively restore the function of the nasal cavity.

关 键 词：慢性鼻窦炎 吉雷开窍汤 鼻腔菌群 鼻腔功能 鼻腔鼻窦结局测试-20量表 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]