祛风散结汤联合中药熏蒸治疗神经性皮炎疗效研究  

Curative effect of Qufeng Sanjie decoction combined with Chinese herbal fumigation in treatment of neurodermatitis

作　　者：董小天 周美惠 DONG Xiaotian;ZHOU Meihui(Traditional Chinese Medicine Department,Air Force Hospital in the Eastern War Zone of the Chinese People’s Liberation Army,Nanjing 210000,China)

机构地区：[1]解放军东部战区空军医院,江苏南京210000

出　　处：《陕西中医》2025年第4期495-498,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：江苏省高校自然科学基金资助面上项目(KJ2023C001-D030)。

摘　　要：目的:探讨祛风散结汤联合中药熏蒸治疗神经性皮炎的疗效及对患者外周血Th1/Th2细胞因子、P物质(SP)、单胺氧化酶(MAO)的影响。方法:选取90例神经性皮炎患者,采用数字表法分为对照组、研究组,每组45例,对照组采用丙酸氯倍他索乳膏治疗,研究组采用中药熏蒸、口服中药联合丙酸氯倍他索乳膏治疗,两组均治疗4周。对比两组患者EASI评分、VAS评分、DLQI评分、外周血Th1/Th2细胞因子水平、血清SP、MAO水平和总体疗效。结果:治疗后研究组EASI、VAS、DLQI评分较治疗前降低,且研究组评分低于对照组(均P<0.05)。治疗后研究组、对照组血清IFN-γ、IL-2水平升高,IL-4、IL-5水平降低(均P<0.05);研究组血清IFN-γ、IL-2水平明显高于对照组,IL-4、IL-5水平显著低于对照组(均P<0.05)。治疗后研究组、对照组血清SP、MAO水平降低,研究组血清SP、MAO水平明显低于对照组(均P<0.05);研究组总有效率高于对照组(P<0.05)。结论:祛风散结汤联合中药熏蒸及丙酸氯倍他索乳膏治疗ND可缩短病程,显著提高临床疗效,改善患者生活质量,且用药安全。Objective:To investigate the curative effect of Qufeng Sanjie decoction combined with Chinese medicine fumigation in the treatment of neurodermatitis and the influence on Th1/Th2 cytokines,Substance P(SP)and monoamine oxidase(MAO)in peripheral blood of patients.Methods:90 patients with neurodermatitis were selected and divided into a control group and a study group using a digital table method,with 45 patients in each group.The control group was treated with chlorhexidine propionate cream,while the study group was treated with traditional Chinese medicine fumigation,oral Chinese medicine combined with chlorhexidine propionate cream.Both groups were treated for 4 weeks.Compare the EASI score,VAS score,DLQI score,peripheral blood Th1/Th2 cytokine levels,serum SP,MAO levels,and overall efficacy between two groups of patients.Results:After treatment,EASI,VAS and DLQI scores of the study group were lower than those before treatment,and the scores of the study group were lower than those of the control group(all P<0.05).After treatment,the serum levels of IFN-γ and IL-2 in study group and control group were increased,while the levels of IL-4 and IL-5 were decreased(all P<0.05).Serum IFN-γ and IL-2 levels of study group were significantly higher than those of control group,and serum IL-4 and IL-5 levels were significantly lower than those of control group(all P<0.05).After treatment,the serum SP and MAO levels in the study group and the control group were decreased,and the serum SP and MAO levels in the study group were significantly lower than those in the control group(all P<0.05).The total effective rate of the study group were higher than those of the control group(P<0.05).Conclusion:Qufeng Sanjie decoction combined with traditional Chinese medicine fumigation and clobetasol propionate cream in the treatment of ND can shorten the course of the disease,significantly improve the clinical effect,improve the quality of life of patients,and the drug is safe.

关 键 词：神经性皮炎 祛风散结汤 TH1/TH2细胞因子 P物质 单胺氧化酶 生活质量 

分 类 号：R758.3[医药卫生—皮肤病学与性病学]