益气养血方治疗非小细胞肺癌根治术后咳嗽疗效及对患者炎症因子的影响  

Effect of Yiqi Yangxue prescription on cough after radical treatment of non-small cell lung cancer and its influence on inflammatory factors

作　　者：朱鹏飞 蒋国鹏 张云杰[2] 宿广峰[1] ZHU Pengfei;JIANG Guopeng;ZHANG Yunjie;SU Guangfeng(Department of Thoracic Surgery,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of General Surgery,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学附属医院胸外科,山东济南250014 [2]山东中医药大学附属医院普外科,山东济南250014

出　　处：《陕西中医》2025年第4期499-503,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：山东省自然科学基金资助面上项目(ZR2021MH297)。

摘　　要：目的:基于“通调三焦”理论探究益气养血方治疗非小细胞肺癌(NSCLC)患者根治术后咳嗽的疗效。方法:选取150例行NSCLC根治术后咳嗽的患者,随机分为观察组(75例)和对照组(75例)。两组均采用常规止咳化痰治疗方案,在此基础上,对照组另予孟鲁司特钠片口服,观察组在对照组的基础上给予益气养血方治疗。比较两组患者临床疗效、中医证候积分、肺通气功能指标[肺活量(FVC)、呼气峰值流速(PEF)、第一秒用力呼气量占所有呼气量比例(FEV1/FVC)、肺一氧化碳弥散量(DLCO)、最大呼气中段流量(MMEF)、最大分钟通气量(MVV)]、炎症因子[高迁移率族蛋白B1(HMGB1)、CXC趋化因子配体10(CXCL10)和血清淀粉样蛋白A(SAA)],记录治疗期间不良反应发生情况。结果:治疗结束后,观察组整体疗效优于对照组,复发率和中医证候积分显著低于对照组(均P<0.05)。两组患者FVC、PEF、FEV1/FVC、DLCO、MMEF、MVV水平相较治疗前显著提升,观察组较对照组改善更为明显(均P<0.05)。两组炎症因子HMGB1、CXCL10、SAA水平较治疗前显著降低,且观察组低于对照组(均P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:益气养血方治疗NSCLC患者根治术后咳嗽疗效显著,可有效降低中医证候积分,增强肺通气功能,降低炎症反应,药物安全性较好。Objective:Based on the theory of“Tongtiao Sanjiao”to explore the therapeutic effect of Yiqi Yangxue prescription on cough after radical surgery in patients with non-small cell lung cancer(NSCLC).Methods:150 patients with cough after undergoing radical resection for NSCLC were selected.By random coin tossing method,the participants were divided into observation group(digit side,75 cases)and control group(flower side,75 cases).Both groups were treated with conventional cough relief and phlegm resolving treatment.On this basis,the control group was additionally given montelukast sodium tablets,while the observation group was added with Yiqi Yangxue prescription on the basis of the control group.The clinical efficacy,TCM syndromes scores,pulmonary ventilation function indicators[forced vital capacity(FVC),peak expiratory flow(PEF),proportion of forced expirations in the first second to forced vital capacity(FEV1/FVC),lung carbon monoxide diffusing capacity(DLCO),maximum mid-expiratory flow(MMEF),and maximum voluntary ventilation(MVV)],inflammatory factors[high-mobility group box-1 protein(HMGB1),CXC chemokine ligand 10(CXCL10)and serum amyloid A(SAA)]were compared between the two groups before and after treatment,and the occurrence of adverse reactions during treatment was recorded.Results:After the end of treatment,the efficacy rate of the treatment in the observation group was markedly superior to that of the control group,and both the relapse rate and the scores for TCM symptoms were considerably lower in the observation group compared to the control group(all P<0.05).The levels of pulmonary ventilation function indicators FVC,PEF,FEV1/FVC,DLCO,MMEF and MVV in the two groups of patients were significantly improved compared with those before treatment,the enhancements observed in the observation group were notably more pronounced and surpassed those of the control group with statistical significance(all P<0.05).The levels of inflammatory factors HMGB1,CXCL10 and SAA in two groups were significantly lower than b

关 键 词：非小细胞肺癌 通调三焦 益气养血方 术后咳嗽 疗效 炎症因子 

分 类 号：R273[医药卫生—中西医结合]