基于“亢火害物”探讨结直肠“炎-癌转化”及防治思路  

The prevention and treatment of colorectal“inflammation cancer transformation”based on“raging inferno and injuring wu”

作　　者：宁永波 罗珍莲 宋子豪 王雅兴 陈香颖 陈嘉齐 吴存恩 薛维伟[1] 壮雨雯 NING Yongbo;LUO Zhenlian;SONG Zihao;WANG Yaxing;CHEN Xiangying;CHEN Jiaqi;WU Cunen;XUE Weiwei;ZHUANG Yuwen(Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]江苏省中医院,江苏南京210029

出　　处：《陕西中医》2025年第4期512-516,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(82205210);江苏省中医院院级课题(Y2020CX67)。

摘　　要：结直肠癌是常见的消化道恶性肿瘤。炎症被认为是导致大肠癌的主要原因之一,其产生的炎症微环境显著增加了结直肠癌的发病风险。故改善肿瘤炎症微环境,减缓“炎-癌转化”进程,对结直肠癌的防治有重要意义。中医火热毒邪与现代医学中的炎症关系密切,基于中医“取象比类”思维及临床医学研究,认为“亢火害物”可用来描述“炎-癌转化”的发展过程。“亢火”作为“炎-癌转化”发生的基础贯穿始终,“害物”则是其形成的根本原因。亢盛之火蓄积,一方面熏蒸肠腑衍生气滞、痰浊、瘀毒等邪实,另一方面伤害正气,损耗精血,使人体处于虚损状态而不能祛邪于外,最终因火成毒致虚、因虚生火聚毒成恶性循环,推动了“炎-癌转化”的进展。基于此,治疗应遵循中医“亢害承制”思想,纠人体正邪之偏颇,补益气血之虚,清降火性毒邪之实,减轻炎性浸润,防止“炎症-发育不良-癌”转化序列的形成,从而有效降低结直肠癌的发病率。Colorectal cancer is a common malignant tumor of the gastrointestinal tract.Inflammation is considered to be one of the main causes of colorectal cancer,and the inflammatory microenvironment it generates significantly increases the risk of colorectal cancer.Therefore,improving the inflammatory microenvironment of tumors and slowing down the process of“inflammation-cancer transformation”are of great significance to the prevention and treatment of colorectal cancer.According to Chinese medicine,fire-heat toxicity is closely related to inflammation in modern medicine.Based on the analogy by appearance of Chinese medicine and modern medical research,the author believes that“raging inferno and injuring wu”can be used to describe the development process of“inflammation cancer transformation”.“Raging inferno”is the basis for the development of“inflammation cancer transformation”throughout the whole process,and“injuring wu”is the root cause of its formation.Hyperactive fire accumulation on the one hand can be transformed into poison fumigation bowel derived from it,on the other hand,the harm loss of positive qi,so that the human body is in a state of deficiency and can not get rid of the evil in the outside,which makes the fire become toxic to the deficiency,and the fire and toxicity due to the deficiency into a vicious circle,accelerates the process of“inflammation cancer transformation”.Therefore,for the treatment of“Kang hai cheng zhi”should take care of both positive and negative aspects,replenish the deficiency of human body’s qi and blood,clear and reduce the reality of fire and toxicity,reduce the inflammatory infiltration,prevent the formation of“inflammation-dysplasia-cancer”transformation sequence,so as to effectively reduce the development of colorectal cancer.

关 键 词：结直肠癌 亢火害物 亢害承制 炎-癌转化 炎症 微环境 

分 类 号：R273[医药卫生—中西医结合]