基于“燥伤肺络”理论探析肺纤维化  

To explore pulmonary fibrosis based on the theory of“dryness and injury to the lung meridian”

作　　者：茆春阳 杜燕 雷伟伟 周波[3] 牛阳 MAO Chunyang;DU Yan;LEI Weiwei;ZHOU Bo;NIU Yang(Ningxia Regional Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of High Incidence,Yinchuan 750004,China;Ningxia Regional Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of High Incidence,Ningxia Medical University,Yinchuan 750004,China;School of Traditional Chinese Medicine,Ningxia Medical University,Yinchuan 750004,China;Shizuishan Second People’s Hospital,Shizuishan 753000,China)

机构地区：[1]宁夏区域高发病中西医结合防治研究重点实验室,宁夏银川750004 [2]宁夏少数民族医药现代化教育部重点实验室,宁夏银川750004 [3]宁夏医科大学中医学院,宁夏银川750004 [4]石嘴山市第二人民医院,宁夏石嘴山753000

出　　处：《陕西中医》2025年第4期522-526,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金区域创新发展联合基金资助项目(U20A20404);国家中医药管理局高水平中医药重点学科温病学学科建设项目(ZYYZDXK-2023209);全国名老中医药专家传承工作室建设项目[国中医药人教函(2022)75号];宁夏自然科学基金资助项目(2023AAC03212);宁夏医科大学校级科研项目(XY2024218)。

摘　　要：“燥伤肺络”理论是根据肺的生理特点与燥邪致病特点提出。肺叶娇嫩,喜清润而恶干燥,肺络散布在肺叶之间,其宣发肃降之功可调节水液代谢运行,外感燥邪,或内伤火热,易侵袭肺叶,津液损耗,损伤肺络。从发病过程来看,燥邪入络,与津血搏结,日久迁延不愈,符合络病学说“久病入络”特点,并与肺纤维化起病隐匿、病程日久、缠绵难愈的特点相一致。文章通过进一步阐释燥邪致病特点与肺络受损的机制变化,“燥伤肺络”机制形成特点,以及“燥伤肺络”理论指导肺纤维化防治,为后续开展肺纤维化燥邪致病基础研究提供思路,为燥邪影响下肺纤维化的临床诊疗和预防提供理论依据。The theory of“dryness damaging the lung meridian”is proposed based on the physiological characteristics of the lungs and the pathogenic characteristics of dryness.The lung lobes are delicate and prefer to be clear and moist,but dislike dryness.The lung meridians are scattered between the lung lobes,and their function of promoting and descending can regulate the metabolism of water and fluids.External infection of dryness and evil,or internal injury of heat and fire,can easily invade the lung lobes,cause fluid loss,and damage the lung meridians.From the perspective of the pathogenesis,the entry of pathogenic factors into the meridians,coupled with the stagnation of fluid and blood,persists for a long time without healing,which is consistent with the characteristic of“prolonged disease entering the meridians”in the theory of collateral diseases.It is also consistent with the insidious onset and prolonged course of pulmonary fibrosis,which is difficult to cure.The article further elaborates on the pathogenic characteristics of dry pathogens and the mechanism changes of lung meridian damage,the formation characteristics of the“dry injury lung meridian”mechanism,and the theoretical guidance of“dry injury lung meridian”for the prevention and treatment of pulmonary fibrosis,providing ideas for the subsequent basic research on the pathogenic characteristics of dry pathogens in pulmonary fibrosis,and providing theoretical basis for the clinical diagnosis,treatment,and prevention of pulmonary fibrosis under the influence of dry pathogens.

关 键 词：肺痿 肺纤维化 燥邪 肺络 燥伤肺络 滋阴润燥 

分 类 号：R563[医药卫生—呼吸系统]