基于数据挖掘探讨名中医邹必英教授中医药治疗原发性胆汁性胆管炎的用药规律  

Medication rule of Professor Zou Biying in the treatment of primary biliary cholangitis with traditional Chinese medicine based on data mining

作　　者：王箭焱 吕婕 陈玉麟 邹必英 陈述 WANG Jianyan;LYU Jie;CHEN Yulin;ZOU Biying;CHEN Shu(Department of Hepatology,Jiujiang Traditional Chinese Medicine Hospital,Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市中医医院肝病科,江西九江332000

出　　处：《中国当代医药》2025年第7期28-33,共6页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0995)。

摘　　要：目的本研究通过数据挖掘方法,探讨江西省名中医邹必英教授中医药治疗原发性胆汁性胆管炎(PBC)的用药规律。方法选取2019年1月至2023年12月九江市中医医院邹必英教授开具的188例PBC患者的住院及门诊处方作为研究对象,建立数据库,采用数据挖掘技术对其用药规律进行系统分析。采用频数分析、关联规则、聚类分析等数据挖掘方法,对病证结合、证候要素、用药频次、组方规律等进行探讨。结果邹必英教授治疗PBC主要以疏肝利胆、健脾和胃、活血化瘀为治疗原则。在治疗胁痛方面,常用茯苓、香附等;在治疗黄疸方面,常用车前子、赤芍等;在治疗水肿方面,常用白术、泽泻等;在治疗燥证方面,常用北沙参、麦冬等;在治疗血证方面,常用大腹皮、茜草等。这些处方体现了邹必英教授在辨证施治中的个体化用药原则。结论邹必英教授强调注重病因病机辨证用药和个体化用药,这为进一步提升PBC的中医药治疗水平提供了科学依据和理论支持,也为广大临床医生提供了借鉴。Objective Through the method of data mining,this study explored the medication rule of Professor Zou Biying in the treatment of primary biliary cholangitis(PBC)with traditional Chinese medicine.Methods The inpatient and outpatient prescriptions of 188 PBC patients issued by Professor Zou Biying from Jiujiang Traditional Chinese Medicine Hospital from January 2019 to December 2023 were selected as the research objects,and a database was established to systematically analyze his medication rules by using data mining technology.Data mining methods such as frequency analysis,association rules and cluster analysis were used to discuss the combination of disease and syndrome,syndrome elements,drug frequency and formula formation law.Results Professor Zou Biying mainly treated PBC with the principles of soothing liver and gallbladder,strengthening spleen and stomach,promoting blood circulation and removing blood stasis.In the treatment of hypochondriac pain,Poria,Cyperus rotundus and so on were commonly used.In the treatment of jaundice,Plantain seed,Red peony and so on were commonly used.In the treatment of edema,Atractylodes macrocephala,Rhizoma alismatis and so on were commonly used.In the treatment of dryness syndrome,Radix glehniae and Ophiopogon and so on were commonly used.In the treatment of blood syndrome,Pericarpium arecae,Madder and so on were commonly used.These prescriptions embody Professor Zou Biying's principle of individualized medicine in the treatment of syndrome differentiation.Conclusion Professor Zou Biying emphasized the importance of etiology and pathogenesis differentiation and individualized drug use,which provided scientific basis and theoretical support for further improving the level of traditional Chinese medicine treatment of PBC,and also provided reference for the majority of clinicians.

关 键 词：原发性胆汁性胆管炎 中医药 邹必英 数据挖掘 用药规律 

分 类 号：R259[医药卫生—中西医结合]