短效与长效硝苯地平治疗妊娠期高血压疾病的效果比较  

Comparison of the efficacy of short-acting and long-acting nifedipine in the treatment of gestational hypertension

作　　者：符音 刘冰 张丁丹 Fu Yin;Liu Bing;Zhang Dingdan(Department of Obstetrics,Zhengzhou Yihe Hospital,Zhengzhou 450000,China;Department of GynecologyⅡ,the First Hospital of Harbin,Harbin 150000,China)

机构地区：[1]郑州颐和医院产科,郑州450000 [2]哈尔滨市第一医院妇二科,哈尔滨150000

出　　处：《中国实用医刊》2025年第2期103-106,共4页Chinese Journal of Practical Medicine

摘　　要：目的比较短效与长效硝苯地平在妊娠期高血压疾病中的应用效果。方法队列研究。抽取2021年1月至2022年12月郑州颐和医院收治的妊娠期高血压疾病患者78例,按随机数字表法分为短效组和长效组,每组39例。短效组采用短效硝苯地平治疗,长效组采用长效硝苯地平治疗。比较两组血压[收缩压(SBP)、舒张压(DBP)]、24 h尿蛋白、分娩结局及并发症发生情况。结果治疗后,长效组SBP、DBP低于短效组(P<0.05)。治疗后,长效组24 h尿蛋白水平低于短效组(P<0.05)。长效组自然分娩率(71.79%,28/39)高于短效组(35.90%,14/39),P<0.05;长效组剖宫产率(28.21%,11/39)低于短效组(64.10%,25/39),P<0.05。长效组并发症发生率(7.69%,3/39)低于短效组(25.64%,10/39),P<0.05。结论与短效硝苯地平相比,长效硝苯地平治疗妊娠期高血压疾病的效果更好,能快速降低患者血压,改善尿蛋白指标和分娩结局,减少产后出血、胎儿窘迫、胎盘早剥等并发症的发生。Objective To compare the application effect of short-acting and long-acting nifedipine in the treatment of gestational hypertension.Methods A total of 78 patients with gestational hypertension treated in Zhengzhou Yihe Hospital from January 2021 to December 2022 were selected for the cohort study,and they were divided into the short-acting group and the long-acting group according to random number table method,with 39 cases in each group.The short-acting group was treated with short-acting nifedipine,and the long-acting group was treated with long-acting nifedipine.The blood pressure,including systolic blood pressure(SBP)and diastolic blood pressure(DBP),24 h urine protein,delivery outcome and incidence of complications were compared between the two groups.ResultsAfter treatment,the levels of SBP and DBP in the long-acting group were lower than those in the short-acting group(P<0.05).After treatment,the level of 24 h urine protein in the long-acting group was lower than that in the short-acting group(P<0.05).The natural delivery rate in the long-acting group(71.79%,28/39)was higher than that in the short-acting group(35.90%,14/39),P<0.05;and the cesarean section rate in the long-acting group(28.21%,11/39)was lower than that in the short-acting group(64.10%,25/39),P<0.05.The incidence of complications in the long-acting group(7.69%,3/39)was lower than that in the short-acting group(25.64%,10/39),P<0.05.Conclusions Compared with short-acting nifedipine,long-acting nifedipine is more effective in the treatment of gestational hypertension.It can quickly reduce blood pressure,improve urinary protein indicators and delivery outcomes,and reduce the incidence of complications,such as postpartum hemorrhage,fetal distress and placental abruption.

关 键 词：硝苯地平 妊娠期高血压 长效 短效 

分 类 号：R54[医药卫生—心血管疾病]