Escalation of soya cross-allergy in infants with cow's milk allergy  

作　　者：Bhaswati C Acharyya Meghdeep Mukhopadhyay 

机构地区：[1]Department of Pediatric Gastroenterology and Hepatology,Institute of Child Health,Kolkata 700017,West Bengal,India [2]Department of Paediatric Gastroenterology,Manipal Hospital,Kolkata 700099,West Bengal,India

出　　处：《World Journal of Clinical Pediatrics》2025年第2期88-92,共5页世界临床儿科杂志(英文)

摘　　要：BACKGROUND Cow's milk allergy(CMA)is a common condition in infants,requiring alternative protein sources in their diets.Soya milk has become a popular substitute,especially in developing countries where it is a more affordable option compared to expensive hypoallergenic feeds for infants with insufficient breast milk supply.However,recent observations have shown an increase in soya cross-allergic reactions among infants with CMA.AIM To determine how often infants diagnosed with CMA also had soya cross-allergy and to examine the symptoms and outcomes of these infants at 2 years of age.METHODS Data from two pediatric centers were analyzed,looking at clinical records of children under 2 years old diagnosed with CMA from August 2015 to July 2023,divided into two four-year periods.RESULTS The records of 432 infants with CMA were analyzed.In the first four-year period from August 2015 to July 2019,142 infants were studied,with 27(19%)found to have soya-protein allergy as well.In the second four-year period,a total of 290 infants were studied,and soya allergy was found in 136 babies(47%).This represents a significant increase(P<0.0001)in cases of soya protein cross-allergy among infants with CMA.The most common symptoms observed were gastroesophageal reflux disorder(39%),followed by failure to thrive,bloody diarrhea,watery diarrhea,and constipation.At 2 years of age,these infants showed significant growth failure compared to infants with CMA only.CONCLUSION In conclusion,this study emphasizes the importance of being cautious when using soy protein in infants with cow's milk protein allergy,especially in areas where cost is a major concern.

关 键 词：Cow's milk allergy Soya allergy Escalation of allergy INFANTS IgE mediated Non-IgE mediated 

分 类 号：R72[医药卫生—儿科]