Advancements in prenatal diagnosis and management of hypoplastic left heart syndrome:A multidisciplinary approach and future directions  

作　　者：Syed Faqeer Hussain Bokhari Syed M Faizan Sattar Umair Mehboob Muhammad Umais Muhammad Ahmad Ahmad Malik Danyal Bakht Asma Iqbal Wahidullah Dost 

机构地区：[1]Department of Medicine and Surgery,King Edward Medical University,Lahore 54000,Punjab,Pakistan [2]Curative Medicine,Kabul University of Medical Sciences,Kabul 10001,Kābul,Afghanistan

出　　处：《World Journal of Cardiology》2025年第3期25-40,共16页世界心脏病学杂志(英文)

摘　　要：Hypoplastic left heart syndrome is a severe congenital defect involving underdeveloped left-sided cardiac structures,leading to significant mortality and morbidity.Prenatal diagnosis using fetal ultrasound and echocardiography enables early detection,family counseling,and improved clinical decision-making.Advanced prenatal interventions,such as fetal aortic valvuloplasty and atrial septostomy,show promise but require careful patient selection.A multidisciplinary approach involving obstetricians,neonatologists,and pediatric cardiologists is vital for effective management.Future directions include refining imaging techniques,such as three-dimensional ultrasound,cardiovascular magnetic resonance imaging,and exploring bioengineering solutions,stem cell therapies,and genetic research.These advancements aim to improve therapeutic options and address current limitations,including transplant scarcity and postoperative complications.Although surgical innovations have improved survival rates,challenges remain,including neurological risks and long-term hemodynamic issues.Ongoing research and technological advancements are essential to enhance outcomes and quality of life for hypoplastic left heart syndrome patients.

关 键 词：Congenital disorder CARDIOLOGY Hypoplastic left heart syndrome Fetal ultrasound Congenital heart disease 

分 类 号：R54[医药卫生—心血管疾病]