脂质组学在糖尿病肾病研究中的应用进展  

Application Progress of Lipidomics in Diabetic Nephropathy

作　　者：董政委 杨康 李遇伯[2] 赵换 DONG Zhengwei;YANG Kang;LI Yubo;ZHAO Huan(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]河南中医药大学第一附属医院,郑州450000 [2]天津中医药大学,天津301617

出　　处：《世界科学技术-中医药现代化》2025年第2期321-328,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：河南省卫生健康委国家中医临床研究基地科研专项(2022JDZX109):基于肾小管上皮细胞外泌体调控的PPARγ信号通路探讨补阳还五汤干预肾间质纤维化的作用机制,负责人:杨康。

摘　　要：糖尿病肾病(Diabetic nephropathy,DN)是导致糖尿病(Diabetes mellitus,DM)患者高死亡率的一种慢性并发症。诸多研究者致力于DN的诊断、病因、进展及治疗的分子机制。随着小分子脂质在肾功能和DN发病机制中调控作用逐渐清晰,脂质组学也成为DN研究中的有力工具。DN具有脂质代谢紊乱的特点,脂质组学因其特有的针对性,在DN的脂质代谢谱表征、诊断、机制探究及治疗方面发挥着重要的作用。但同时,机体内的脂质又是复杂的,这给脂质的检测与分析带来了巨大的挑战。未来多学科交叉及多组学的联用是脂质组学突破的方向。本篇文章概述了脂质组学在DN研究策略、脂质代谢谱表征、早期诊断、药物疗效及机制探索及组学联合分析中的应用进展,并进一步讨论了未来DN脂质组学应用的机遇与挑战,以期为相关方向的研究人员提供一个清晰的研究现状及前景。Diabetic nephropathy(DN)is a chronic complication that leads to the high mortality of diabetes mellitus(DM)patients.Many researchers are devoted to the diagnosis,etiology,process and molecular mechanism of treatment of DN.At present,the regulation of small molecular lipids on renal function and the role in the pathogenesis of DN are gradually becoming clear,and lipidomics has also become a powerful tool in DN research.DN is characterised by disorders of lipid metabolism,and lipidomics plays an important role in the characterisation of lipid metabolic profiles,diagnosis,mechanistic investigation and treatment of DN because of its unique relevance.But at the same time,the lipids in the body are complex,which brings great challenges to the detection and analysis of lipids.In the future,multidisciplinary crossover and multi-omics association is the direction of lipidomics breakthrough.This article outlines the progress of the application of lipidomics in DN research strategies,lipid metabolic profiling,early diagnosis,drug efficacy and mechanism exploration,and histological co-analysis,and further discusses the opportunities and challenges of the future application of lipidomics in DN,with the aim of providing a clear picture of the current status of the research and the prospects for researchers in the relevant directions.

关 键 词：糖尿病肾病 糖尿病 脂质组学 生物标志物 应用进展 

分 类 号：R587.2[医药卫生—内分泌]