基于“表观遗传-糖代谢重编程”论结直肠癌“脾不散精”病机的科学内涵  

The Scientific Connotation of the Pathogenesis of"Dysfunction of Spleen Transforming Essences"in Colorectal Cancer Based on"Epigenetic-Reprogramming of Glucose Metabolism"

作　　者：樊秀梅 黄文博 李雪珂 由凤鸣[1,3] 李芳[1] 肖冲[1,2] FAN Xiumei;HUANG Wenbo;LI Xueke;YOU Fengming;LI Fang;XIAO Chong(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;Department of Teaching and Research of Tumor,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;Cancer Research Institute,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)

机构地区：[1]成都中医药大学附属医院,成都610072 [2]成都中医药大学肿瘤学教研室,成都610072 [3]成都中医药大学肿瘤研究所,成都610072

出　　处：《世界科学技术-中医药现代化》2025年第2期460-465,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：中国博士后科学基金会地区专项支持计划(2022MD723718):基于MondoA-TXNIP轴抑制免疫应答探讨四神丸阻延结肠炎癌转化的机制,负责人:肖冲;四川省科学技术厅四川省自然科学基金(2023NSFSC1830):“火不暖土”视角下MondoA抑制CD8+T细胞免疫应答促结肠炎癌转化及四神丸干预研究,负责人:肖冲。

摘　　要：表观遗传修饰紊乱促进糖代谢重编程是结直肠癌进展的关键环节。基于中医脾为后天之本与表观遗传、脾气散精与糖代谢之间的诸多研究,结合中医药治疗结直肠癌的丰富经验及在糖代谢中的研究积累,可认为结直肠癌“表观遗传-糖代谢重编程”病理是其“脾不散精”关键病机的微观实质,并提出“助脾”逆转表观遗传修饰紊乱“、散精”调复糖代谢的助脾散精治法以治疗结直肠癌。以期丰富“脾不散精”病机的科学内涵,为中医药干预结直肠癌提供新思路及潜在的实证依据。The key link to colorectal cancer progression is that epigenetic derangements promote reprogramming of glucose metabolism.Based on many studies on the relationship between spleen being the origin of acquired constitution and epigenetics,spleen qi dispersing essence and glucose metabolism,combined with the extensive experience of traditional Chinese medicine in the treatment of colorectal cancer and the accumulation of researches on glucose metabolism,it is believed that the"epigenetic-reprogramming of glucose metabolism"pathology of colorectal cancer is the microscopic essence of the key pathogenesis of"dysfunction of spleen transforming essences".The"promoting spleen and dispersing essences"method means that"promoting spleen"to reverse epigenetic derangements and"dispersing essences"to regulate reprogramming of glucose metabolism was put forward to treat colorectal cancer.Look forward to enrich the scientific connotation of the pathogenesis of"dysfunction of spleen transforming essences",new ideas and potential empirical basis for traditional Chinese medicine intervention in colorectal cancer were provided.

关 键 词：糖代谢重编程 表观遗传 脾不散精 助脾散精 

分 类 号：R273[医药卫生—中西医结合]