SII、NLR、PLR水平与老年脓毒症预后的相关性  

Correlation Between the Levels of SII,NLR,PLR and the Prognosis of Sepsis in the Elderly

作　　者：刘琼兴 陈荣琳[2] 路亚丽 黄冠[3] LIU Qiongxing;CHEN Ronglin;LU Yali;HUANG Guan(School of Medicine,Shantou University,Shantou 515041,Guangdong,China;Intensive Care Unit,Shenzhen Longgang Central Hospital,Shenzhen 518116,Guangdong,China;Department Pathology,Shenzhen Longgang Central Hospital,Shenzhen 518116,Guangdong,China)

机构地区：[1]汕头大学医学院,广东汕头515041 [2]深圳市龙岗中心医院重症医学科,广东深圳518116 [3]深圳市龙岗中心医院病理科,广东深圳518116

出　　处：《医学信息》2025年第6期123-126,共4页Journal of Medical Information

基　　金：深圳医学研究基金(编号:C2401019)。

摘　　要：目的研究系统免疫炎症指数(SII)、中性粒细胞与淋巴细胞计数比值(NLR)、血小板与淋巴细胞计数比值(PLR)水平与老年脓毒症患者预后的相关性。方法选取2022年1月-2023年12月深圳市龙岗中心医院重症医学科收治的96例老年脓毒症患者为研究对象,依据28 d内患者预后分为生存组(81例)、死亡组(15例),比较两组患者临床资料 年龄、性别、APACHEⅡ评分及SII、NLR、PLR水平,并分析SII水平与老年脓毒症患者预后危险因素的独立相关性。结果生存组血清SII、去甲肾上腺素使用时间、去甲肾上腺素使用总量、呼吸机使用时间、感染情况与死亡组比较,差异有统计学意义(P<0.05);两组性别、年龄、APACHEⅡ评分、SOFA评分、NLR、PLR等指标比较,差异无统计学意义(P>0.05);Spearman相关性分析显示,SII与去甲肾上腺素使用总量、呼吸机和去甲肾上腺素使用时间均无明显相关性(P>0.05)。结论SII水平对老年脓毒症病情程度和预后具有一定的预测价值,可作为临床评估其病情严重程度和预后的辅助指标,值得临床应用。Objective To study the correlation between systemic immune inflammation index(SII),neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)and prognosis in elderly patients with sepsis.Methods A total of 96 elderly patients with sepsis admitted to the Intensive Care Unit,Shenzhen Longgang Central Hospital from January 2022 to December 2023 were selected as the research objects.According to the prognosis of patients within 28 days,they were divided into survival group(81 patients)and death group(15 patients).The clinical data(age,gender,APACHEⅡscore,SII,NLR and PLR levels)of the two groups were compared,and the independent correlation between SII level and prognostic risk factors of elderly patients with sepsis was analyzed.Results There were significant differences in serum SII,norepinephrine use time,total norepinephrine use,ventilator use time and infection between the survival group and the death group(P<0.05).There was no significant difference in gender,age,APACHEⅡscore,SOFA score,NLR and PLR between the two groups(P>0.05).Spearman correlation analysis showed that there was no significant correlation between SII and total norepinephrine use,ventilator and norepinephrine use time(P>0.05).Conclusion The level of SII has a certain predictive value for the severity and prognosis of sepsis in the elderly,which can be used as an auxiliary index to evaluate the severity and prognosis of sepsis in the elderly.It is worthy of clinical application.

关 键 词：SII NLR PLR 脓毒症 

分 类 号：R631.2[医药卫生—外科学]