法尼醇X受体对血糖代谢的调控作用  

Regulation of Farnesoid X Receptor on Blood Glucose Metabolism

作　　者：杨璈 钟世林 YANG Ao;ZHONG Shilin(The First Clinical Medical College,Guangdong Medical University,Zhanjiang 524023,Guangdong,China;Department of Obstetrics and Gynecology,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong,China;Institute of Obstetrics and Gynecology,Shenzhen PKU-HKUST Medical Center,Shenzhen 518036,Guangdong,China;Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases,Shenzhen518036,Guangdong,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524023 [2]北京大学深圳医院妇产中心,广东深圳518036 [3]深圳北京大学香港科技大学医学中心妇产科学研究所,广东深圳518036 [4]深圳市女性重大疾病早期诊断技术重点实验室,广东深圳518036

出　　处：《医学信息》2025年第6期168-172,共5页Journal of Medical Information

基　　金：深圳市科技计划项目(编号:JCYJ20210324110206017);深圳市高水平医院建设专项经费(编号:粤办函〔2019〕260号);深圳市“医疗卫生三名工程”项目(编号:SZSM202011016)。

摘　　要：法尼醇X受体(FXR)是一种胆汁酸受体,参与了胆汁酸的合成、运输、重吸收和调节糖代谢等重要过程。特别是在糖代谢方面,肝脏中的FXR有调节糖异生和糖原合成的作用,肠道中的FXR可以通过多种途径调节肠道吸收和转运葡萄糖。研究表明,FXR有可能成为控制糖尿病的一个靶点。然而,关于妊娠期FXR如何调节血糖仍需要进一步探讨。考虑到肠道菌群也可能参与FXR调节糖代谢的过程,需要进一步探讨肠道菌群-FXR通路在妊娠期血糖代谢调节中的作用。本文主要从肝脏或肠道中FXR对血糖代谢的调控以及对妊娠期血糖代谢方面相关研究进行综述,旨在为进一步探索FXR对妊娠期血糖代谢功能影响及机制提供参考。The farnesoid X receptor(FXR)is a bile acid receptor that plays a key role in the synthesis,transport,reabsorption of bile acids,and the regulation of glucose metabolism.In the liver,FXR regulates gluconeogenesis and glycogen synthesis,making it crucial for glucose metabolism.Moreover,in the gut,FXR is involved in regulating intestinal glucose absorption and transport through various pathways.These findings suggest that FXR could potentially be targeted for controlling diabetes mellitus.However,the specific role of the FXR pathway in glucose regulation during pregnancy needs further clarification.Considering that intestinal flora may also be involved in the process of FXR regulating glucose metabolism,it is necessary to further explore the role of intestinal flora-FXR pathway in the regulation of blood glucose metabolism during pregnancy.This article mainly reviews the regulation of FXR on blood glucose metabolism in the liver or intestine and the related research on blood glucose metabolism during pregnancy,aiming to provide a reference for further exploring the effect and mechanism of FXR on blood glucose metabolism during pregnancy.

关 键 词：法尼醇X受体 血糖代谢 妊娠期糖尿病 2型糖尿病 胆汁酸 

分 类 号：R587.1[医药卫生—内分泌]