不同剂量瑞舒伐他汀钙片对急性心肌梗死患者经皮冠状动脉介入术后心室重构、心功能及血脂的影响  

Effects of different doses of rosuvastatin calcium tablets on ventricular remodeling,cardiac function and blood lipid in patients with acute myocardial infarction after percutaneous coronary intervention

作　　者：王子阳 宋学卓 侯玉玲 WANG Ziyang;SONG Xuezhuo;HOU Yuling(Department of Cardiology,Harbin 242nd Hospital,Harbin 150000,China;不详)

机构地区：[1]哈尔滨二四二医院心内科,哈尔滨市150000 [2]哈尔滨市第一医院心内科,150000

出　　处：《临床合理用药》2025年第11期4-7,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：黑龙江省医药卫生科研课题(20230909020466)。

摘　　要：目的观察不同剂量瑞舒伐他汀对急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术后心室重构、心功能及血脂的影响。方法选取2019年1月—2021年12月哈尔滨二四二医院收治的AMI患者60例,通过随机数字表法分为观察组和对照组各30例。2组PCI术后均给予常规治疗,在此基础上,观察组与对照组分别给予瑞舒伐他汀钙片40 mg和20 mg口服,均为每天1次,且2组均连续治疗1个月。比较2组治疗前后左室重构指标[左室舒张末期内径(LVEDD)、室间隔厚度(LVST)、左室后壁厚度(LVPWT)、左室质量指数(LVMI)]、左室舒缩功能指标[左室等容舒张时间(IVRT)、左室短轴缩短率(LVFS)、左室射血分数(LVEF)]、血脂指标[血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]及不良反应。结果治疗1个月后,2组LVEDD、LVST、LVPWT、LVMI及TC、TG、LDL-C水平低于治疗前,IVRT、LVFS、LVEF及HDL-C水平高于治疗前,且观察组低/高于对照组(P<0.05或P<0.01)。观察组与对照组不良反应总发生率比较差异无统计学意义(26.67%vs.23.33%,χ^(2)=0.089,P=0.766)。结论瑞舒伐他汀能抑制AMI患者PCI术后心室重构,促进心功能恢复,改善血脂指标,且大剂量(40 mg/d)瑞舒伐他汀治疗的效果更加明显。Objective To observe the effects of different doses of rosuvastatin on ventricular remodeling,cardiac function and blood lipid in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods Sixty patients with AMI admitted to Harbin 242nd Hospital from January 2019 to December 2021 were selected and divided into observation group and control group with 30 patients in each group by random number table method.The two groups were given conventional treatment after PCI.On this basis,the observation group and the control group were given respectively rosuvastatin calcium tablets 40 mg and 20 mg orally,once a day,and the two groups were treated continuously for 1 month.Left ventricular remodeling indexes(LVEDD,LVST,LVPWT,LVMI),left ventricular diastolic function indexes(IVRT,LVFS,LVEF),blood lipid indexes(TC,TG,LDL-C,HDL-C)before and after treatment,and adverse reactions were compared between two groups.Results After 1 month of treatment,the LVEDD,LVST,LVPWT,LVMI and levels of TC,TG,LDL-C in two groups were lower than before treatment,the IVRT,LVFS,LVEF and level of HDL-C were higher than before treatment,and the levels of observation group were lower/higher than control group(P<0.05 or P<0.01).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(26.67%vs.23.33%,χ^(2)=0.089,P=0.766).Conclusion Rosuvastatin can inhibit ventricular remodeling in AMI patients after PCI,promote the recovery of cardiac function and improve blood lipid indexes,and the effect of large dose of rosuvastatin(40 mg/d)is more obvious.

关 键 词：急性心肌梗死 经皮冠状动脉介入术 瑞舒伐他汀 不同剂量 心室重构 心功能 血脂 

分 类 号：R54[医药卫生—心血管疾病]