小剂量阿司匹林+硫酸镁在妊娠高血压患者中的应用效果及对收缩压、舒张压的影响  

Effect of low-dose Aspirin and Magnesium Sulfate on systolic and diastolic blood pressure in pregnant hypertensive patients

作　　者：陈晓燕 陈琼梅 CHEN Xiaoyan;CHEN Qiongmei(Department of Maternity Care,Quanzhou Maternal and Child Health Hospital,Children's Hospital,Fujian Province,Quanzhou 362000,China)

机构地区：[1]福建省泉州市妇幼保健院·儿童医院妇保科,福建泉州362000

出　　处：《中国当代医药》2025年第8期55-57,62,共4页China Modern Medicine

摘　　要：目的分析小剂量阿司匹林+硫酸镁在妊娠高血压患者中的应用效果及对收缩压、舒张压的影响。方法选取2018年1月至2022年12月泉州市妇幼保健院妇保科收治的50例妊娠高血压患者作为研究对象,采用随机摸球法将其分为对照组和观察组,每组25例。对照组采用常规硫酸镁治疗,观察组采用小剂量阿司匹林联合硫酸镁治疗。比较两组的血压指标、24 h尿蛋白定量、血尿素氮、全血黏度水平、脐动脉阻力指数、并发症情况。结果观察组治疗后的舒张压、收缩压水平均低于对照组,差异有统计学意义(P<0.05);观察组治疗后的24 h尿蛋白定量、血尿素氮、全血黏度水平及脐动脉阻力指数均低于对照组,差异有统计学意义(P<0.05);观察组的并发症总发生率(4.00%)低于对照组(24.00%),差异有统计学意义(P<0.05)。结论小剂量阿司匹林联合硫酸镁方案,用于治疗妊娠高血压患者,其血压水平有效降低,可改善临床指标,且不良反应少。Objective To analyze the effect of low-dose Aspirin and Magnesium Sulfate on systolic and diastolic blood pressure in pregnant hypertensive patients.Methods Fifty pregnant hypertensive patients from January 2018 to December 2022 in the Department of Maternity Care,Quanzhou Maternal and Child Health Hospital were selected as the study objects.They were divided into control group and observation group by random ball-touching method,with 25 cases in each group.The control group was treated with conventional Magnesium Sulfate,and the observation group was treated with low-dose Aspirin combined with Magnesium Sulfate.Blood pressure index,24 h urinary protein quantity,blood urea nitrogen,whole blood viscosity level,umbilical artery resistance index and complications were compared between the two groups.Results The diastolic blood pressure and systolic blood pressure of observation group were lower than those of control group after treatment,and the differences were statistically significant(P<0.05).After treatment,24 h urinary protein quantity,blood urea nitrogen,whole blood viscosity level and umbilical artery resistance index in observation group were lower than those in control group,the differences were statistically significant(P<0.05).The total complication rate of the observation group(4.00%)was lower than that of the control group(24.00%),and the difference was statistically significant(P<0.05).Conclusion Low dose Aspirin combined with Magnesium Sulfate regimen for the treatment of pregnancy-induced hypertension patients,the blood pressure level can be effectively reduced,clinical indicators can be improved,and adverse reactions are less.

关 键 词：妊娠期 高血压 小剂量 阿司匹林 硫酸镁 舒张压 收缩压 

分 类 号：R714[医药卫生—妇产科学]