基质金属蛋白酶3在骨骼系统中双重调控作用机制的最新研究进展  

Latest Research Progress on Dual Regulatory Mechanisms of Matrix Metalloproteinase 3 in Skeletal System

作　　者：刘仪[1] 赵和平[1] 齐茜 于燕[1] LIU Yi;ZHAO Heping;QI Xi;YU Yan(Department of Clinical Laboratory,Honghui Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710054,China)

机构地区：[1]西安交通大学附属红会医院检验科,西安710054

出　　处：《现代检验医学杂志》2025年第2期208-213,220,共7页Journal of Modern Laboratory Medicine

摘　　要：随着人口老龄化问题日益严重,类风湿关节炎(RA)、骨关节炎(OA)、强直性脊柱炎(AS)以及骨质疏松症(OP)等骨关节疾病的发病率正在逐步上升。基质金属蛋白酶3(MMP-3)作为基质金属蛋白酶(MMPs)家族中的重要成员,具有双重调控作用。一方面,它参与了软骨损伤和关节功能障碍等病理过程,在多种骨关节疾病的发生和进展中发挥负向调控作用;另一方面,MMP-3也在早期胚层分化、颌面部骨骼形成、神经元轴突再生、软骨骨化和脂肪细胞分化等方面具有正向调控作用。该文综述了MMP-3的结构和功能,以及其在RA,OA,AS和OP等疾病中的负调控作用,同时探讨了其在生长发育和创伤愈合中的正调控作用。该文还分析了MMP-3在骨关节疾病中双重调控作用的机制,并总结了MMP-3抑制剂的研究进展,以期为相关临床研究提供新的思路和见解。With the increasing problem of an aging population,the incidence of osteoarticular diseases such as rheumatoid arthritis(RA),osteoarthritis(OA),ankylosing spondylitis(AS)and osteoporosis(OP)is gradually rising.Matrix metalloproteinase 3(MMP-3),as an important member of the matrix metalloproteinases(MMPs)family,plays a dual regulatory role.On one hand,it is involved in pathological processes such as cartilage damage and joint dysfunction,exerting a negative regulatory effect in the occurrence and progression of various osteoarticular diseases.On the other hand,MMP-3 has positive regulatory effects in early embryonic layer differentiation,craniofacial bone formation,neuronal axon regeneration,cartilage ossification,and adipocyte differentiation.This article reviewed the structure and function of MMP-3 as well as its negative regulatory roles in diseases such as in RA,OA,AS and OP,while exploring its positive regulatory roles in growth,development and wound healing.The article also analyzed the dual regulatory mechanisms of MMP-3 in bone and joint diseases,and summarized the research progress of MMP-3 inhibitors,in order to provide new ideas and insights for related clinical research.

关 键 词：基质金属蛋白酶3 双重调控作用 骨关节疾病 创伤愈合 

分 类 号：R684[医药卫生—骨科学] R446.11[医药卫生—外科学]