脓毒血症早期诊断血清学标志物及预测模型研究进展  

Research Progress on Serological Markers and Prediction Models for Early Diagnosis of Sepsis

作　　者：史健 熊朝亮 雷静 刘泽世[2] 耿燕 SHI Jian;XIONG Chaoliang;LEI Jing;LIU Zeshi;GENG Yan(College of Medical Technology,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China;Department of Clinical Laboratory,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China)

机构地区：[1]陕西中医药大学医学技术学院,陕西咸阳712000 [2]西安交通大学第二附属医院检验科,西安710004

出　　处：《现代检验医学杂志》2025年第2期214-220,共7页Journal of Modern Laboratory Medicine

摘　　要：脓毒血症是危重患者死亡的主要原因,早期识别感染类型是决定患者治疗和预后的关键。目前,血培养作为脓毒血症诊断的金标准,但因其培养周期长且阳性率较低等局限性,而无法为临床早期开展抗感染治疗提供病原学依据。血清学标志物因其在体外检测方便快捷,且可作为早期推断感染的有益实验室指标而受到广泛关注。近年来,随着各领域对脓毒血症的深入研究,许多新型血清学标志物被发现在诊断脓毒血症方面具有潜在应用价值。因此,该文就近年研究报道的脓毒血症的新型血清学标志物的特点及应用价值进行探讨,以期发现有价值的早期诊断脓毒血症的新型血清学标志物,并结合相关预测模型进行综述,为临床早期诊断脓毒血症带来新思路。Sepsis constitutes a predominant cause of mortality in critically ill patients,and early determination of the type of infection is crucial for influencing patient management and forecasting outcomes.Currently,blood culture serves as the gold standard for diagnosing sepsis.Yet,its limitations,such as a lengthy culture period and low positivity rate,hinder its ability to provide a microbiological basis for early initiation of antimicrobial therapy in clinical practice.Serological markers have engendered significant interest due to their convenience and rapid detection in vitro,emerging as indispensable laboratory indices for early inference of infection.In recent years,with extensive research on sepsis across diverse academic domains,numerous novel serological markers exhibit promise in diagnosing sepsis.Therefore,this review explores the characteristics and applicatron value of new serological markers for early diagnosis of sepsis,and reviews them in combination with relevant predictive models,bringing new ideas for early clinical diagnosis of sepsis.

关 键 词：脓毒血症 血清学标志物 感染 诊断 预测模型 

分 类 号：R631[医药卫生—外科学] R446[医药卫生—临床医学]