荧光磁性纳米粒子合成及其性能  

Synthesis and Properties of Fluorescent Magnetic Nanoparticles

作　　者：仝婧婧 谢涛 李祥刚 郑虹丽 殷倩妹 冯妍 TONG Jingjing;XIE Tao;LI Xianggang;ZHEN Hongli;YIN Qianmei;FENG Yan(College of Packaging and Materials Engineering,Hunan University of Technology,Zhuzhou Hunan 412007,China)

机构地区：[1]湖南工业大学包装与材料工程学院,湖南株洲412007

出　　处：《包装学报》2025年第2期69-77,共9页Packaging Journal

基　　金：国家自然科学基金国家重大科研仪器研制项目(51927810);湖南省教育厅科学研究基金资助项目(24A0412)。

摘　　要：为实现纳米粒子的荧光磁性双功能化,设计并合成一种强荧光超顺磁性的双功能复合材料。将罗丹明B(RhB)染色剂与聚乙二醇(PEG)共价偶联,然后通过氢键作用将聚乙二醇-罗丹明B(PEG-RhB)键合到Fe_3O_4表面。PEG的存在可以形成有效的空间屏障,不仅减缓了Fe_3O_4纳米粒子由于磁偶极相互作用而导致的团聚现象,还减少了RhB直接与磁性粒子表面接触。此外,该粒子的成功制备可以实现磁场-重力场耦合下实时观测磁性纳米粒子的链结构。Fe_3O_4-PEG-RhB在靶向治疗、荧光标记和磁流体密封等方面有着巨大的应用潜力。In order to realize the fluorescence magnetic bifunctionalization of nanoparticles,a bifunctional composite material with highfluorescence superparamagnetism was successfully designed.The rhodamine B(RhB)dye was covalently coupled with polyethylene glycol(PEG),and then the polyethylene glycol-rhodamine B(PEG-RhB)was successfully bonded to the surface of the ferric oxide(Fe3O4)through the hydrogen bonding.An effective space barrier was established due to the presence of PEG,which not only prevented the agglomeration of Fe3O4 nanoparticles through the magnetic dipole interaction,but also reduced the direct contact between RhB and the surface of magnetic particles.Moreover,the chain structure of magnetic nanoparticles can be observed in real time under the condition of magneticfield-gravityfield coupling,which has great application potential in targeted therapy,fluorescence labeling and magneticfluid seal and so on.

关 键 词：荧光磁性纳米粒子 Fe_3O_4 荧光标记 罗丹明B 

分 类 号：TB34[一般工业技术—材料科学与工程]