RNA结合蛋白基于RNA代谢调节在骨关节炎中发挥作用  

RNA-binding proteins regulate osteoarthritis via RNA metabolism regulation

作　　者：苏婧玥 陈思宇 杨胜武[2] 邓桢翰 SU Jingyue;CHEN Siyu;YANG Shengwu;DENG Zhenhan(Graduate School,Guangxi University of Chinese Medicine,Nanning,530001;Department of Orthopaedic Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou Zhejiang 325000;Department of Sports Medicine,Shenzhen Second People’s Hospital(First Affiliated Hospital of Shenzhen University),Shenzhen Guangdong 518035,China)

机构地区：[1]广西中医药大学研究生院,南宁530001 [2]温州医科大学附属第一医院骨科,浙江温州325000 [3]深圳市第二人民医院(深圳大学第一附属医院)运动医学科,广东深圳518035

出　　处：《中南大学学报(医学版)》2024年第12期1973-1982,共10页Journal of Central South University :Medical Science

基　　金：广东省基础与应用基础研究基金(2023A1515220072,2021A1515220030)。

摘　　要：骨关节炎(osteoarthritis,OA)是骨骼系统和肌肉系统常见的慢性退行性病变,目前致病机制仍不明确,因此尚缺乏有效治疗措施。核糖核酸结合蛋白(ribonucleic acid binding proteins,RBP)作为参与转录后调控的关键因子,可靶向结合核糖核酸(ribonucleic acid,RNA)并调节其功能和命运。通过对包括转录、剪接、修饰、稳定和翻译在内的RNA代谢过程进行调控,RBP可影响OA的发生和发展。探讨RBP在生理病理状态下的调控机制,阐述RBP在OA发生和发展中的作用,分析目前RBP研究的困难及未来的研究方向,对靶向RBP的OA治疗具有重要意义。Osteoarthritis(OA)is a common chronic degenerative disease of the skeletal system and muscular system,and its pathogenesis remains unclear,leading to a lack of effective therapeutic strategies.Ribonucleic acid binding proteins(RBP),as key regulators of post transcriptional processes,can specifically bind to targeted ribonucleic acids(RNA)and modulate their function and fate.By regulating various aspects of RNA metabolism,including transcription,splicing,modification,stabilization,and translation,RBPs influence the onset and progression of OA.Exploring the regulatory mechanisms of RBPs under physiological and pathological conditions,elucidating the role of RBPs in the occurrence and development of OA,and discussing current challenges and future directions in RBPs research,hold significant importance for the treatment of OA by targeting RBPs.

关 键 词：RNA结合蛋白 骨关节炎 RNA代谢 基因表达调控 

分 类 号：R58[医药卫生—内分泌]