乙肝疫苗接种后差异性免疫应答个体的T细胞特征  

T cell characteristics in individuals with different immune responses after hepatitis B vaccination

作　　者：韩智勇 王丹 贺晓燕 夏嫱 HAN Zhiyong;WANG Dan;HE Xiaoyan;XIA Qiang(Department of Immunology and Pathogen Biology,Zhuhai Campus of Zunyi Medical University,Zhuhai Guangdong 519041,China)

机构地区：[1]遵义医科大学珠海校区免疫与病原生物学教研室,广东珠海519041

出　　处：《中南大学学报(医学版)》2024年第12期1983-1990,共8页Journal of Central South University :Medical Science

基　　金：国家自然科学基金(82060307)。

摘　　要：乙型肝炎是一个全球性的公共卫生问题。通过接种乙肝疫苗诱导机体产生乙型肝炎表面抗体(hepatitis Bsurface antibody,HBsAb)是预防乙型肝炎的重要措施。然而,不同个体对乙肝疫苗的免疫应答水平存在差异。根据HBsAb水平的不同,可以将个体分为高应答、低应答和无应答。T细胞及其亚群在这一免疫调节过程中起重要作用,同时T细胞受体(T cell receptor,TCR)免疫组库的构成也影响机体的免疫应答水平。探究接种乙肝疫苗后差异性免疫应答个体T细胞、T细胞亚群及TCR免疫组库的特征,有望为优化乙肝疫苗和制订更有效的接种策略提供理论支持。Hepatitis B is a global public health concern.Inducing hepatitis B surface antibody(HBsAb)through vaccination is a crucial preventive strategy.However,individuals show varying immune responses to the hepatitis B vaccine.Based on HBsAb levels,individuals can be categorized as high responders,low responders,or non-responders.T cells and their subsets play critical roles in modulating this response,and the composition of the T cell receptor(TCR)repertoire also influences immune responsiveness.Investigating the characteristics of T cells,their subsets,and TCR repertoires in individuals with differential responses post-vaccination may provide theoretical guidance for optimizing vaccine design and immunization strategies.

关 键 词：乙肝疫苗 T细胞 免疫应答 免疫组库 免疫组库测序 T细胞受体 乙型肝炎表面抗体 

分 类 号：R18[医药卫生—流行病学]