脉搏波传导速度评价血管老化的临床研究进展  

Clinical research progress in pulse wave velocity in the assessment of vascular aging

作　　者：吴静静 黎菲 王婕 蔡菁菁[2] 袁洪[1] 陆瑶[1] WU Jingjing;LI Fei;WANG Jie;CAI Jingjing;YUAN Hong;LU Yao(Clinical Research Center,Third Xiangya Hospital,Central South University,Changsha 410013;Department of Cardiology,Third Xiangya Hospital,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院临床试验研究中心,长沙410013 [2]中南大学湘雅三医院心血管内科,长沙410013

出　　处：《中南大学学报(医学版)》2024年第12期1991-1998,共8页Journal of Central South University :Medical Science

基　　金：国家科技重大专项(2023ZD0503900,2023ZD0503901);国家自然科学基金(82170437,81974054);中南大学创新驱动计划(2023CXQD007);中南大学湘雅三医院“汇智育才计划”(BJ202002)。

摘　　要：血管老化是指血管壁结构和血管舒张功能发生退行性改变,这一变化是心血管疾病(cardiovasculardisease,CVD)发生、发展的病理生理基础。脉搏波传导速度(pulse wave velocity,PWV)检测作为一种评估和检测早期血管老化的非侵入性筛查手段,已在预测CVD发病风险及评价药物治疗效果等方面取得了显著成果。通过PWV评估血管老化状态,能有效预测健康个体、高血压患者、糖尿病患者以及慢性炎症性疾病患者等不同健康状态人群的CVD风险。对高血压等慢性病患者,采用抗炎、降脂、降压和降糖等药物治疗能有效降低PWV,从而减缓血管老化的进程。因此,PWV不仅是评价早期血管老化的重要工具,也是衡量药物治疗效果的重要指标。定期监测PWV,对于预测CVD风险、评估药物治疗效果及指导临床决策具有重要意义。Vascular aging refers to the degenerative changes in vascular wall structure and vasodilatory function,forming the pathophysiological basis for the onset and progression of cardiovascular disease(CVD).Pulse wave velocity(PWV),a non-invasive method for evaluating and detecting early vascular aging,has achieved significant results in predicting CVD risk and evaluating the efficacy of pharmacological treatments.PWV can effectively predict CVD risk across various populations,including healthy individuals,patients with hypertension,diabetes,and chronic inflammatory diseases.In patients with comorbidities such as hypertension,pharmacological interventions,such as anti-inflammatory,lipid lowering,anti-hypertensive,and anti-diabetic treatments,can effectively reduce PWV and thus slow down vascular aging.Therefore,PWV is not only a vital tool for assessing early vascular aging but also an important indicator for evaluating treatment outcomes.Regular monitoring of PWV levels is of great significance in predicting CVD risk,evaluating therapeutic efficacy,and guiding clinical decision-making.

关 键 词：血管老化 心血管疾病 脉搏波速度 药物治疗 动脉僵硬度 

分 类 号：R54[医药卫生—心血管疾病]