中药熏蒸对难愈性创面的临床疗效观察  

Analysis on the effect of traditional Chinese medicine fumigation in the treatment of refractory wounds

作　　者：郑刚 曹渭新 付强[1] 欧佳 曹雨 谷才之 Zheng Gang;Cao Weixin;Fu Qiang;Ou Jia;Cao Yu;Gu Caizhi(Department of Burns Plastic and Wound Repair Surgery,the Eighth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学第八附属医院烧伤整形创面修复外,乌鲁木齐830000

出　　处：《中华损伤与修复杂志(电子版)》2025年第2期117-121,共5页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

摘　　要：目的观察中药熏蒸治疗难愈性创面的临床效果。方法选择新疆医科大学第八附属医院烧伤整形创面修复外科2022年3月至8月收治的难愈性创面患者50例,采用随机数字表法将患者分为对照组和观察组各25例。对照组给予清创、换药等常规治疗,观察组在常规治疗基础上给予中药熏蒸治疗,比较2组临床疗效、创面肉芽组织病理结构改变、视觉模拟量表(VAS)评分、创面生长因子水平及并发症总发生率。结果观察组临床总有效率(96.00%)高于对照组(72.00%),χ^(2)=5.357,P=0.021。观察组治疗后新生毛细血管、成纤维细胞、巨噬细胞数目均较对照组更高(t=20.485、16.071、8.992,P<0.001)。观察组治疗后VAS评分低于对照组(t=10.645,P<0.001)。观察组治疗后创面组织表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)、血小板衍生生长因子(PDGF)及血管内皮生长因子(VEGF)水平均较对照组更高(t=7.925、11.344、4.892、10.365,P<0.001)。观察组并发症总发生率(4.00%)低于对照组(32.00%),χ^(2)=6.640,P=0.010。结论中药熏蒸可有效改善难愈性创面治疗效果,促进新生肉芽组织生长,减轻创面疼痛,增加创面生长因子,降低并发症发生率。Objective To observe the clinical efficacy of traditional Chinese medicine fumigation in treating refractory wounds.Methods Fifty patients with refractory wounds treated in the Department of Burns and Plastic Surgery and Wound Repair Surgery,the Eighth Affiliated Hospital of Xinjiang Medical University from March to August 2022 were selected and divided into the control group and the observation group randomly according to the random number table method,with 25 cases in each group.The control group was given conventional treatment such as debridement and dressing changes,and the observation group was given traditional Chinese medicine fumigation on the basis of the conventional treatment.The clinical efficacy,granulation histopathologic changes,visual analogue scale(VAS)score,growth factor and total complication rate were compared between the two groups.Results The total effective rate of the observation group(96.00%)was higher than that of the control group(72.00%),χ^(2)=5.357,P=0.021.After treatment,the number of new capillaries,fibroblasts and macrophages in the observation group were higher than those in the control group(t=20.485,16.071,8.992;P<0.001).The VAS score of the observation group was lower than that of the control group(t=10.645,P<0.001).The levels of epidermal growth factor(EGF),basic fibroblast growth factor(bFGF),platelet-derived growth factor(PDGF)and vascular endothelial growth factor(VEGF)in the observation group were higher than those in the control group(t=7.925,11.344,4.892,10.365;P<0.001).The total complication rate of the observation group(4.00%)was lower than that of the control group(32.00%),χ^(2)=6.640,P=0.010.Conclusion Traditional Chinese medicine fumigation can effectively improve the clinical efficacy of refractory wounds,promote the growth of new granulation tissue,reduce the wound pain,increase the expression of growth factor,and reduce the incidence of complications.

关 键 词：中药熏蒸 难愈性创面 肉芽组织 创面修复 

分 类 号：R47[医药卫生—护理学]