基于上皮嵴微结构的移植物在促进创面愈合中的作用机制与临床应用进展  

Advances in the mechanism and clinical application of rete ridges microstructure- based grafts in promoting wound healing

作　　者：靳顺欣 庞嘉越成 肖仕初 Jin Shunxin;Pang Jiayuecheng;Xiao Shichu(Department of Burn Surgery,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院烧伤外科,上海200433

出　　处：《中华损伤与修复杂志(电子版)》2025年第2期174-178,共5页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：国家自然科学基金(82372513、82172201、81871559)。

摘　　要：上皮嵴(RRs)是皮肤真皮与表皮结合部位的结构单元,由基部、斜坡和尖端3个部分组成。RRs通过增加表皮与真皮的接触面积,促进二者机械连接,增强皮肤的机械性能和稳定性。RRs还在优化皮肤营养供应、促进干细胞增殖和分化等方面发挥作用。RRs的形成受到物理应力、细胞张力和分子信号传导的调控。在皮肤组织工程中,RRs的微结构重建是促进创面愈合和提高移植物性能的重要一环。近年来,研究者通过光刻、3D打印等技术,成功制备了包含RRs微结构的生物材料和移植物,为创面修复提供了新思路。尽管,目前研究已取得了一定进展,但仍存在RRs标准化制备、材料选择、细胞类型与培养条件等问题。本文通过综述RRs的结构特点、形成机制及其在皮肤组织工程中的应用,阐述RRs在创面愈合中的重要性,以期为复杂创面修复提供有效技术支持。Rete ridges(RRs)are structural units located at the dermal-epidermal junction of the skin,consisting of a base,slope,and tip.By increasing the contact area between the epidermis and dermis,RRs facilitate mechanical interlocking between the two layers,thereby enhancing the mechanical properties and stability of the skin.Additionally,RRs contribute to optimizing nutrient supply,promoting stem cell proliferation and differentiation,and maintaining skin homeostasis.The formation of RRs is regulated by physical stress,cellular tension,and molecular signaling pathways.In skin tissue engineering,the reconstruction of RRs microstructures plays a critical role in promoting wound healing and improving graft performance.Recent advancements have enabled the fabrication of biomaterials and grafts incorporating RRs microstructures through techniques such as photolithography and 3D printing,offering new approaches for wound repair.Despite these advancements,challenges remain in the standardized fabrication of RRs,material selection,cell types,and culture conditions.This review summarizes the structural characteristics,formation mechanisms,and applications of RRs in skin tissue engineering,highlights their significance in wound healing to provide effective technological solutions for complex wound repair.

关 键 词：上皮嵴 创面愈合 生物支架 皮肤组织工程 

分 类 号：O65[理学—分析化学]