离子型谷氨酸受体参与心脏系统疾病发生发展的研究进展  

Ionic Glutamate Receptor Involved in Occurrence and Development of Cardiac Diseases

作　　者：胡艺千 杨波[1] HU Yiqian;YANG Bo(Department of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute of Wuhan University,Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院心内科,武汉大学心血管病研究所,心血管病湖北省重点实验室,湖北武汉430060

出　　处：《心血管病学进展》2025年第3期230-234,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(82170316)。

摘　　要：心血管疾病是全球发病率与死亡率最高的疾病之一,其发病机制非常复杂。谷氨酸是一种能介导中枢神经系统兴奋性突触传播的神经递质。谷氨酸受体是一种离子型受体,存在于神经系统、心脏及部分外周器官,主要介导兴奋性递质的传播,与钙内流、炎症发生、氧化应激等一系列反应相关,参与动脉粥样硬化性心脏病、高血压、心律失常等心血管疾病的发生发展。现综述离子型谷氨酸受体对心脏系统疾病发生发展的影响及其潜在的分子机制。Cardiovascular disease is one of the highest morbidity and mortality diseases in the world,and its pathogenesis is very complex.Glutamate is a neurotransmitter that mediates excitatory synaptic transmission in the central nervous system.Glutamate receptor is an ionic receptor that exists in the nervous system,heart and some peripheral organs.It mainly mediates the transmission of excitatory transmitters and is related to a series of reactions such as calcium influx,inflammation,oxidative stress,etc.,and is involved in the occurrence and development of atherosclerotic heart disease,hypertension,arrhythmia and other cardiovascular diseases.This article reviews the effects of ionic glutamate receptors on the occurrence and development of cardiac diseases and their potential molecular mechanisms.

关 键 词：谷氨酸受体 离子型受体 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]