蛋白质O-GlcNAc修饰在心血管系统中的损伤作用  

Harmful Effect of Protein O-GlcNAc Modification in Cardiovascular System

作　　者：周媛媛[1] 梁羽 ZHOU Yuanyuan;LIANG Yu(Department of Anesthesiology,Guanghan People’s Hospital,Guanghan 618300,Sichuan,China;Department of Anesthesiology,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu 610072,Sichuan,China)

机构地区：[1]广汉市人民医院麻醉科,四川德阳618300 [2]四川省医学科学院·四川省人民医院(电子科技大学附属医院)麻醉手术中心,四川成都610072

出　　处：《心血管病学进展》2025年第3期235-239,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(82300925)。

摘　　要：心脏蛋白质O-连接β-N-乙酰葡萄糖胺(O-GlcNAc)修饰的激活通常与细胞代谢的改变有关,其急性升高可保护心脏免受心脏缺血再灌注损伤,但O-GlcNAc修饰持续激活会对心血管造成不利影响,引起心律失常、心力衰竭、糖尿病心肌病和血管疾病等多种心血管疾病,其主要与心肌钙信号、心肌蛋白、转录因子、内皮型一氧化氮合酶、微RNA的改变等有关。现主要讨论蛋白质O-GlcNAc修饰对心血管的损伤效应及机制研究进展,以期为心血管疾病的治疗提供新思路及药物治疗靶点。Activation of protein O-linked β-N-acetylglucosamine(O-GlcNAc) modification in heart is often associated with the changes in cell metabolism,the acute increase of protein O-GlcNAc modification protects the heart from ischaemia reperfusion injury,but the continuous activation of O-GlcNAc modification is harmful to cardiovascular function,resulting in multiple cardiovascular diseases,like arrhythmia,heart failure,diabetic cardiomyopathy,and vascular disease,which is related to the changes in myocardial calcium signal,muscle proteins,transcription factors,endothelial nitric oxide synthase,microRNA,and other mechanisms.This article mainly summarizes the research progress on the cardiovascular injury effect and mechanism of O-GlcNAc modification,aiming to provide new insights and drug therapeutic targets for the treatment of cardiovascular diseases.

关 键 词：O-连接β-N-乙酰葡萄糖胺修饰 心血管系统 心力衰竭 糖尿病心肌病 

分 类 号：R54[医药卫生—心血管疾病]