OGG1在糖尿病心肌病中的研究进展  

Research Progress of OGG1 in Diabetic Cardiomyopathy

作　　者：陈洪侨 吴子君 吴铿 CHEN Hongqiao;WU Zijun;WU Keng(Graduate School of Guangdong Medical University,Zhanjiang 524023,Guangdong,China;Department of Cardiovascular Medicine,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524002,Guangdong,China)

机构地区：[1]广东医科大学研究生院,广东湛江524023 [2]广东医科大学附属医院心血管内科,广东湛江524002

出　　处：《心血管病学进展》2025年第3期240-244,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81670348)。

摘　　要：糖尿病心肌病是由糖尿病引起的一种独立于高血压、冠状动脉疾病和结构性心脏病等具有明确病因的特异性心肌病。引起糖尿病心肌病的发病机制复杂多样,包括氧化应激和线粒体功能障碍等。8-羟基鸟嘌呤DNA糖苷酶1(OGG1)能使受损的线粒体功能恢复正常,从而维持生命体正常的能量供应,目前许多研究已证实其在癌症、免疫、神经退行性疾病及心血管疾病等领域中扮演了非常重要的角色。OGG1与糖尿病心肌病的发生发展密切相关,值得进一步研究和开发相关的治疗策略,现就OGG1在糖尿病心肌病发病机制中的作用进行综述。Diabetic cardiomyopathy is a kind of specific cardiomyopathy caused by diabetes,independent of hypertension,coronary artery disease and structural heart disease.The pathogenesis of diabetic cardiomyopathy is complex and diverse,including oxidative stress and mitochondrial dysfunction.8-Oxoguanine DNA glycosylase 1(OGG1) can restore the damaged mitochondrial function to normal,so as to maintain the normal energy supply of living organisms.Many studies have confirmed that OGG1 plays an important role in cancer,immunity,neurodegenerative diseases and cardiovascular diseases.OGG1 is closely related to the occurrence and development of diabetic cardiomyopathy,which is worthy of further research and development of related treatment strategies.This article reviews the role of OGG1 in the pathogenesis of diabetic cardiomyopathy.

关 键 词：糖尿病 糖尿病心肌病 8-羟基鸟嘌呤DNA糖苷酶1 氧化应激 线粒体功能障碍 

分 类 号：R54[医药卫生—心血管疾病]