细叶石头花根石油醚部位化学成分研究  

Chemical constituents from the petroleum ether fraction of the roots of Gypsophila licentiana

作　　者：郜志宁 邱田田 崔天义 孙孝亚 薛淑娟[1] 陈随清[1,2] GAO Zhi-ning;QIU Tian-tian;CUI Tian-yi;SUN Xiao-ya;XUE Shu-juan;CHEN Sui-qing(College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Key Laboratory of Chinese Medicine Resources and Chinese Medicine Chemistry,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]河南省中药资源与中药化学重点实验室,河南郑州450046

出　　处：《中成药》2025年第3期821-827,共7页Chinese Traditional Patent Medicine

基　　金：河南省中药材产业技术体系(豫农科教[2018]14号);河南省药品监督管理局科技计划(2020DB042)。

摘　　要：目的研究细叶石头花根石油醚部位的化学成分。方法采用硅胶、Sephadex LH-20及半制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到18个化合物,分别鉴定为邻苯二甲酸二丁酯(1)、二十烷酸-1-甘油酯(2)、对苯二甲酸二辛酯(3)、9,12-十八烷二烯酸甲酯(4)、(3′S,4′S)-3′-acetoxy-4′-angeloyloxy-3′,4′-dihydroseselin(5)、二氢阿魏酸(6)、邻苯二甲酸二(2-乙基)己酯(7)、2,2′-oxybis(1,4)-di-tert-butylbenzene(8)、丝石竹皂苷元(9)、3-keto,16α-hydroxy,24-noroleanolic acid(10)、齐墩果酮酸(11)、10-eicosenoic acid(12)、腊酸(13)、enniatin B(14)、(R,Z)-21-methyl-8-pentatriacontene(15)、没食子酸乙酯(16)、stellarine A(17)、正二十五烷(18)。结论所有化合物均为首次从细叶石头花根中分离得到。AIM To study the chemical constituents from the petroleum ether fraction of the roots of Gypsophila licentiana Hand.-Mazz.METHODS Silica gel,Sephadex LH-20 and semi-preparative HPLC were used for isolation and purification,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Eighteen compounds were isolated and identified as dibutyl phthalate(1),glyceryl arachidate(2),bis(2-ethylhexyl)terephthalate(3),9,12-octadecadienoic acid(Z,Z)-methyl ester(4),(3′S,4′S)-3′-acetoxy-4′-angeloyloxy-3′,4′-dihydroseselin(5),3-(4-hydroxy-3-methoxyphenyl)-propanoic acid(6),bis(2-ethylhexyl)phthalate(7),2,2′-oxybis(1,4)-di-tert-butylbenzene(8),gypsogenin(9),3-keto,16α-hydroxy,24-noroleanolic acid(10),3-oxo-olean-12-en-28-oic acid(11),10-eicosenoic acid(12),hexacosanic acid(13),enniatin B(14),(R,Z)-21-methyl-8-pentatriacontene(15),ethyl gallate(16),stellarine A(17),pentacosane(18).CONCLUSION All compounds are isolated from this plant for the first time.

关 键 词：细叶石头花 根 山银柴胡 石油醚部位 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]