68Ga-Pentixafor PET/CT在原发性醛固酮增多症分型中的临床价值  

Clinical value of 68Ga-Pentixafor PET/CT in classification of subtypes of primary aldosteronism

作　　者：张娜 谢阳 陈跃 Zhang Na;Xie Yang;Chen Yue(Department of Nuclear Medicine,the Affiliated Hospital of Southwest Medical University,Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province,Institute of Nuclear Medicine,Southwest Medical University,Luzhou 646000,China)

机构地区：[1]西南医科大学附属医院核医学科、核医学与分子影像四川省重点实验室、西南医科大学核医学研究所,泸州646000

出　　处：《中华核医学与分子影像杂志》2025年第3期185-188,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：泸州市科学技术和人才工作局-核医学创新转化平台(2021LZXNYD-P03)。

摘　　要：原发性醛固酮增多症(PA)是继发性高血压最常见的病因,是心血管和代谢性疾病的危险因素之一。其发病率随高血压级别升高而增加。早期诊断及治疗至关重要。PA分型是其诊断过程的重点、难点,与后续治疗决策紧密相关。肾上腺静脉采血(AVS)虽是PA分型诊断的"金标准",但其为昂贵、操作难度大的侵入性检查,在临床上难以推广。68Ga-Pentixafor PET/CT属无创影像学检查,能可视化病灶并对病灶进行定位与定性,有助于PA的分型诊断。该文就68Ga-Pentixafor PET/CT在PA分型诊断中的研究进行综述。Primary aldosteronism(PA)is one of the most common causes of secondary hypertension,and is one of the risk factors of cardiovascular and metabolic diseases.Its incidence increases with the increase of hypertension level.The early diagnosis and treatment of PA are important.The subtype classification of PA is vital but challenging,which is related to the treatment options.Although adrenal vein sampling(AVS)is currently recognized as the gold standard for subtype diagnosis of PA,it′s an invasive test that is technically challenging and expensive,which limits its clinical use.As a non-invasive imaging method,68Ga-Pentixafor PET/CT can visualize,locate and characterize the lesions,and facilitate PA subtyping.This article reviews the research of 68Ga-Pentixafor PET/CT in the subtype diagnosis of PA.

关 键 词：醛固酮增多症 肽类 环 受体 CXCR4 镓放射性同位素 正电子发射断层显像术 体层摄影术 X线计算机 发展趋势 

分 类 号：R586.24[医药卫生—内分泌] R817.4[医药卫生—内科学]