阿司匹林与拉贝洛尔联合硫酸镁治疗妊娠期高血压的临床效果  

Clinical efficacy of aspirin,labetalol and magnesium sulfate combination therapy for pregnancy-induced hypertension

作　　者：王芸 李娟霞[1] 邹娜[1] WANG Yun;LI Juanxia;ZOU Na(Department of Obstetrics,People′s Hospital of Macheng City,Hubei Province,Macheng 438300,China)

机构地区：[1]湖北省麻城市人民医院产科,438300

出　　处：《临床合理用药》2025年第10期36-39,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察阿司匹林与拉贝洛尔联合硫酸镁治疗妊娠期高血压的临床效果。方法回顾性分析2021年7月—2023年7月于麻城市人民医院收治的140例妊娠期高血压患者临床病历资料,根据治疗方案不同分为观察组和对照组,各70例。对照组予硫酸镁注射液治疗,观察组在对照组基础上加用盐酸拉贝洛尔片或注射液及阿司匹林肠溶片治疗。比较2组治疗前后血压(收缩压与舒张压)、超氧化物歧化酶(SOD)及内皮素-1(ET-1)水平变化,母婴结局(包括剖宫产率、产后出血、早产、新生儿窒息、胎儿窘迫、新生儿死亡等),以及不良反应。结果治疗2周后,2组收缩压与舒张压均较治疗前下降,且观察组低于对照组(P<0.01);2组ET-1水平均较治疗前下降,SOD水平上升,且观察组低/高于对照组(P<0.01)。观察组剖宫产率为21.43%,低于对照组的40.00%(χ^(2)=5.673,P=0.017);观察组并发症总发生率低于对照组(22.86%vs.42.86%,χ^(2)=6.346,P=0.012);观察组不良反应总发生率为7.14%,低于对照组的18.57%(χ^(2)=4.080,P=0.043)。结论阿司匹林与拉贝洛尔联合硫酸镁治疗妊娠期高血压疾病的临床效果肯定,对于患者相关指标改善作用明显,且对母婴结局有积极影响,安全可靠。Objective To observe the clinical efficacy of aspirin,labetalol and magnesium sulfate combination therapy for pregnancy-induced hypertension.Methods A retrospective analysis was conducted on the clinical medical records of 140 patients with pregnancy-induced hypertension admitted to People′s Hospital of Macheng City from July 2021 to July 2023.Patients were divided into observation group and control group,each with 70 cases,based on their treatment protocols.The control group was treated with magnesium sulfate injection.The observation group received combination therapy consisting of magnesium sulfate injection,labetalol hydrochloride(tablets or injection),and aspirin enteric-coated tablets.The changes in blood pressure(systolic and diastolic),SOD and ET-1 levels before and after treatment,as well as maternal and infant outcomes(including cesarean section rate,postpartum hemorrhage,preterm birth,neonatal asphyxia,neonatal death,fetal distress,etc.)and adverse reactions were compared between the two groups.Results After two weeks of treatment,both groups showed decrease in systolic and diastolic blood pressure compared to baseline,with the observation group exhibiting significantly lower levels than the control group(P<0.01).Both groups experienced reduction in ET-1 levels and increase in SOD levels compared to baseline,with the observation group demonstrating significantly lower/higher levels than the control group(P<0.01).The cesarean section rate in the observation group was 21.43%,which was lower than the 40.00%in the control group(χ^(2)=5.673,P=0.017).The overall incidence of complications in the observation group was lower than that in the control group(22.86%vs.42.86%,χ^(2)=6.346,P=0.012).The overall incidence of adverse reactions in the observation group was 7.14%,which was lower than the 18.57%in the control group(χ^(2)=4.080,P=0.043).Conclusion The clinical efficacy of aspirin,labetalol and magnesium sulfate combination therapy for pregnancy-induced hypertension is confirmed,demonstrating significan

关 键 词：妊娠期高血压 阿司匹林 拉贝洛尔 硫酸镁 血压 超氧化物歧化酶 内皮素 

分 类 号：R71[医药卫生—妇产科学]