“肠-骨轴”探讨肠上皮细胞外泌体调控骨髓间充质干细胞铁死亡的机制  

Exploring the mechanism of intestinal epithelial cell-derived extracellular vesicles regulating ferroptosis in bone marrow mesenchymal stem cells based on the intestinal-bone axis theory

作　　者：牛明月 董万涛 李昕昕[2] 巩彦龙 黄九妹 杨攀 李书唱 NIU Mingyue;DONG Wantao;LI Xinxin;GONG Yanlong;HUANG Jiumei;YANG Pan;LI Shuchang(The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学附属医院,甘肃兰州730000 [2]甘肃中医药大学,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2025年第3期409-415,共7页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(81960878);甘肃省科技计划项目-重点研发计划(21YF5FA017);兰州市城关区科技人才创新创业项目(2023-rc-7);兰州市科技发展指导性计划项目(2023-ZD-205)。

摘　　要：“肠-骨轴”理论揭示了肠道微生物群与骨骼健康之间复杂的相互作用。本综述聚焦于肠上皮细胞外泌体在调控骨髓间充质干细胞(BMSCs)铁死亡中的作用,探讨了其在“肠-骨轴”中的潜在调节功能。铁死亡是一种与铁依赖性和脂质氧化相关的细胞死亡形式,对BMSCs的成骨分化和骨代谢过程至关重要。肠上皮细胞外泌体通过携带生物活性物质和RNA分子,影响BMSCs的铁死亡过程,进而参与骨组织的重塑和稳态维持。此外,肠上皮细胞外泌体可能通过激活特定的信号通路,如PI3K/AKT/Nrf2和NF-κB,来抑制铁死亡和调节骨代谢。本综述强调了维护肠道健康在预防和治疗骨骼疾病中的重要性,并为未来的研究和治疗提供了新的视角和潜在靶点。The gut-bone axis theory reveals the complex interplay between the gut microbiota and bone health.This review focuses on the role of exosomes from intestinal epithelial cells in regulating the ferroptosis of bone marrow mesenchymal stem cells(BMSCs),and discusses their potential regulatory function in the gut-bone axis.Ferroptosis is a form of cell death associated with iron dependence and lipid peroxidation,which is crucial for the osteogenic differentiation and bone metabolic processes of BMSCs.Intestinal epithelial cell exosomes affect the ferroptosis process of BMSCs by carrying bioactive substances and RNA molecules,thereby participating in the remodeling and homeostasis maintenance of bone tissue.In addition,intestinal epithelial cell exosomes may inhibit ferroptosis and regulate bone metabolism by activating specific signaling pathways,such as PI3K/AKT/Nrf2 and NF-κB.This review emphasizes the importance of maintaining intestinal health in the prevention and treatment of bone diseases,and provides new perspectives and potential targets for future research and treatment.

关 键 词：肠-骨轴 肠上皮细胞 外泌体 骨髓间充质干细胞 铁死亡 研究进展 

分 类 号：R68[医药卫生—骨科学]