糖尿病性骨质疏松症程序性细胞死亡与中药研究进展  

Research progress of programmed cell death and traditional Chinese medicine in diabetic osteoporosis

作　　者：张雨菲 魏梦娟 黄程程 王晨 李洋[3] 王经武[2] ZHANG Yufei;WEI Mengjuan;HUANG Chengcheng;WANG Chen;LI Yang;WANG Jingwu(First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250000,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250000,China;The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250000,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250000 [2]山东中医药大学附属医院,山东济南250000 [3]山东中医药大学第二附属医院,山东济南250000

出　　处：《中国骨质疏松杂志》2025年第3期446-450,共5页Chinese Journal of Osteoporosis

基　　金：山东省中医药科技项目(Z-2022047)。

摘　　要：糖尿病性骨质疏松症(diabetic osteoporosis,DOP)是一种由高糖继发的骨组织结构和骨代谢紊乱的疾病,通常表现为骨密度下降、骨脆性增加等。最新研究发现,程序性细胞死亡(programmed cell death,PCD)在DOP病理过程中起关键作用,包括细胞凋亡、坏死性凋亡、焦亡、自噬、铁死亡等。本文将概述不同类型PCD参与DOP发展的潜在作用机制。此外,中药有效活性成分具有较强的抗氧化等特性,广泛应用于DOP临床治疗。本文进一步揭示中药治疗DOP潜在药物靶点,为中药防治DOP提供新的研究方向。Diabetic osteoporosis(DOP)is a bone disorder result ing from high glucose levels,characterized by decreased bone density and increased fragility.Recent research has identified programmed cell death(PCD)as a key player in the pathological process of DOP,including apoptosis,necroptosis,pyroptosis,autophagy,ferroptosis etc.This review outlines the potential mechanisms of different types of PCD involved in the development of DOP.Additionally,traditional Chinese medicine contains active components with strong antioxidant properties that are widely used for clinical treatment of DOP.This review further reveals potential drug targets for TCM treatment of DOP and provides new research directions for TCM prevention and treatment.

关 键 词：糖尿病性骨质疏松症 中医药 程序性细胞死亡 治疗 

分 类 号：R587.2[医药卫生—内分泌]