铜稳态与疾病研究进展  

Research Progress in Copper Homeostasis and Diseases

作　　者：邱暑婷 谭晓华[1] 邵诗涵 李愉 张盈盈 曹月佳 狄春红[2] QIU Shuting;TAN Xiaohua;SHAO Shihan;LI Yu;ZHANG Yingying;CAO Yuejia;DI Chunhong(School of Public Health,Hangzhou Normal University,Hangzhou 311121,China;Department of Clinical Laboratory,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China)

机构地区：[1]杭州师范大学公共卫生学院,杭州311121 [2]杭州师范大学附属医院检验科,杭州310015

出　　处：《中国医学科学院学报》2025年第1期102-109,共8页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金面上项目(81772168);浙江省自然科学基金(LY23H190001);杭州师范大学研究生科研创新推进项目(2022HSDYJSKY240)。

摘　　要：铜作为人体不可或缺的必需微量元素,在多种生理生化反应中发挥重要作用。铜稳态的失调会导致铜代谢紊乱,引起相关疾病的发生。铜死亡是一种新提出的调节性细胞死亡方式,不同于已知的细胞凋亡、细胞焦亡、坏死性凋亡和铁死亡。近年研究发现多种癌症中存在铜稳态的失调,靶向铜进行疾病治疗有可能成为一种新策略、新思路。本文将对铜的基本特性、铜紊乱相关疾病(门克斯综合征、威尔逊氏病、癌症)及其治疗、铜死亡进行系统综述。As an indispensable trace element in the human body,copper plays an important role in various physiological and biochemical reactions.The dyshomeostasis of copper leads to the disorder of copper metabolism and the occurrence of related diseases.Cuproptosis,a newly proposed regulatory cell death mode,is different from the known apoptosis,pyroptosis,necroptosis,and ferroptosis.Recent studies have found that the dyshomeostasis of copper has been observed in a variety of cancers.Therefore,targeting copper for disease treatment may become a new strategy and a new idea.This article systematically summarizes the fundamental properties of copper,copper dyshomeostasis-related diseases(Menkes syndrome,Wilson’s disease,and cancer)and their treatment,and reviews the research progress in cuproptosis.

关 键 词：铜稳态 铜代谢 铜死亡 癌症 

分 类 号：R13[医药卫生—劳动卫生]