代谢相关疾病与草酸钙结石形成机制的研究进展  

Research Progress in Metabolism-Related Diseases and Formation Mechanism of Calcium Oxalate Stones

作　　者：岑威虎 沈俊 夏莎莎[1] 王强 CEN Weihu;SHEN Jun;XIA Shasha;WANG Qiang(Department of Urology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550000,China;Department of Urology,Guizhou Hospital,The First Affiliated Hospital of Sun Yat-sen University,Guiyang 550000,China)

机构地区：[1]贵州医科大学附属医院泌尿外科,贵阳550000 [2]中山大学附属第一医院贵州医院泌尿外科,贵阳550000

出　　处：《中国医学科学院学报》2025年第1期124-130,共7页Acta Academiae Medicinae Sinicae

基　　金：贵州省卫生健康委科学技术基金(gzwkj2021-220);国家自然科学基金培育项目(gyfynsfc〔2020〕-30);贵州医科大学附属医院博士科研启动基金(gyfybsky-2-31)。

摘　　要：肾结石是泌尿系统最常见的疾病之一,其中以草酸钙结石最多见。机体代谢紊乱引起的疾病,如高血压、糖尿病、肥胖、高血脂、高尿酸等,通过产生活性氧诱导氧化应激和炎症反应等多种途径,导致尿液中草酸盐、尿酸、酸碱度及钙离子浓度的改变,最终影响草酸钙结石的形成。本文综述了代谢性疾病影响草酸钙结石形成的可能途径与机制,为临床防治草酸钙结石提供新的思路。Kidney stones are a urinary system disease with a high incidence,among which calcium oxalate stones are the most common.Metabolic disorders such as hypertension,diabetes,obesity,hyperlipidemia,and hyperuricemia can cause changes in oxalate,uric acid,and pH and calcium ion concentrations in the urine through multiple pathways including inducing oxidative stress and inflammatory responses by generating reactive oxygen species,ultimately affecting the formation of calcium oxalate stones.This article reviews the possible pathways and mechanisms by which metabolic diseases influence the formation of calcium oxalate stones,providing new ideas for the clinical prevention and treatment of calcium oxalate stones.

关 键 词：草酸钙结石 代谢相关疾病 机制 活性氧 

分 类 号：R692.4[医药卫生—泌尿科学]