宏基因组高通量测序辅助诊断日本斑点热一例  

Metagenomic Next-Generation Sequencing-Assisted Diagnosis of Japanese Spotted Fever:Report of One Case

作　　者：阮永春[1] 周宜庆 张海旺[1] 周洁 段金楠 张晓静 李明晖[1] RUAN Yongchun;ZHOU Yiqing;ZHANG Haiwang;ZHOU Jie;DUAN Jinnan;ZHANG Xiaojing;LI Minghui(Department of Infectious Diseases,Shaoxing People’s Hospital,Shaoxing,Zhejiang 312000,China;WillingMed Technology(Beijing)Company Limited,Beijing 100023,China)

机构地区：[1]绍兴市人民医院感染性疾病科,浙江绍兴312000 [2]微岩医学科技(北京)有限公司,北京100023

出　　处：《中国医学科学院学报》2025年第1期146-149,共4页Acta Academiae Medicinae Sinicae

摘　　要：日本斑点热是由日本立克次体感染引起的一种自然疫源性疾病,临床症状缺乏特异性,易误诊。本文报道1例日本斑点热病例,采用宏基因组高通量测序技术在血细胞中检出日本立克次体,经多西环素治疗好转,为该病的临床诊治提供参考。Japanese spotted fever(JSF)is an infectious disease caused by Rickettsia japonica,with nonspecific clinical symptoms and a high risk of misdiagnosis.We reported a case of JSF,in which Rickettsia japonica was detected in blood cells by metagenomic next-generation sequencing.The patient recovered after treatment with doxycycline.This report provides a reference for the clinical diagnosis and treatment of JSF.

关 键 词：日本立克次体 日本斑点热 诊断 宏基因组高通量测序 

分 类 号：R513.3[医药卫生—内科学]