北京地区近10年骨质疏松症流行病学调查:一项单中心30599例汉族人群双能X线吸收法骨密度检查结果分析  

Epidemiological survey of osteoporosis in Beijing over the past decade:a single-center analysis of dual-energy X-ray absorptiometry scans from 30599 individuals

作　　者：周莹 张丹阳 吴立凡 王桂杉 母杰丹 崔成文 石秀秀 董继革[4] 王瑜[2] 许王莉[2] 李晓 ZHOU Ying;ZHANG Danyang;WU Lifan;WANG Guishan;MU Jiedan;CUI Chengwen;SHI Xiuxiu;DONG Jige;WANG Yu;XU Wangli;LI Xiao(Department of Rehabilitation Medicine,Senior Department of Orthopedics,Fourth Medical Center of PLA General Hospital,National Clinical Research Center for Orthopedics,Sports Medicine&Rehabilitation,Beijing 100048,China;Research Center for Statistical Science,School of Statistics,Renmin University of China,Beijing 100872,China;School of Sports Rehabilitation,Tianjin University of Physical Education,Tianjin 301617,China;Rehabilitation Center,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China)

机构地区：[1]中国人民解放军总医院第四医学中心骨科医学部康复医学科,国家骨科与运动康复临床医学研究中心,北京100048 [2]中国人民大学统计科学研究中心,中国人民大学统计学院,北京100872 [3]天津体育学院运动康复学院,天津301617 [4]中国中医科学院望京医院康复治疗中心,北京100102

出　　处：《南方医科大学学报》2025年第3期443-452,共10页Journal of Southern Medical University

基　　金：国家重点研发项目(2023YFC3604905)。

摘　　要：目的分析本中心DXA检查人群骨量分布及骨量的影响因素。方法收集2013年7月~2023年7月在本院行双能X线吸收法(DXA)骨密度检查的30599例20岁以上汉族人群的骨密度结果,并收集其身高、体质量和性别等一般信息,使用R语言软件进行描述性和相关性统计学分析。结果本中心男性腰椎、股骨颈和全髋的骨量峰值分别为1.00±0.12 g/cm^(2)、0.94±0.14 g/cm^(2)、0.99±0.13 g/cm^(2),女性分别为0.99±0.12 g/cm^(2)、0.79±0.11 g/cm^(2)、0.88±0.11 g/cm^(2),男性显著高于女性(腰椎P=0.022,股骨颈P<0.001,全髋P<0.001);成年男性和女性腰椎、股骨骨密度(BMD)值在达到峰值后随着年龄增长而降低;男性和女性各个部位BMD值与体质量指数(BMI)之间存在正向相关关系;2013~2014年男性和女性患者腰椎、髋部、股骨颈BMD值均为近10年最低值,2015~2023年男性和女性患者腰椎、髋部、股骨颈BMD值呈上升趋势。结论不同人群的BMD值存在差异。未来需要采用更精准的BMD检测技术,开展多中心有代表性人群的临床研究,以探索人群BMD值随人口统计学的变化特征。Objective To analyze bone mass distribution and the factors affecting bone mass in a general Chinese Han cohort undergoing physical examinations at our center.Methods We retrospectively collected the data of bone mineral density(BMD)measurements from 30599 healthy Han Chinese adults(age≥20 years)who underwent dual-energy X-ray absorptiometry scans at our hospital from July,2013 to July,2023.Basic parameters including height,body weight,and gender were recorded,and descriptive statistics and correlation analyses were performed using R software.Results In this cohort,the male individuals had a mean peak BMD of 1.00±0.12 g/cm^(2) in the lumbar vertebrae,0.94±0.14 g/cm^(2) in the femoral neck,and 0.99±0.13 g/cm^(2) in the total hip,significantly higher than the values in the female individuals[0.99±0.12 g/cm^(2) in the lumbar vertebrae(P=0.022),0.79±0.11 g/cm^(2) in the femoral neck(P<0.001),and 0.88±0.11 g/cm^(2) in the total hip(P<0.001)].In the overall cohort,the BMD values of the lumbar spine and femur decreased with age after reaching their peak levels.There was a positive correlation between BMD value and body mass index(BMI)in both male and female individuals.The 2013-2014 period recorded the lowest BMD values in the lumbar,hip,and femoral neck,which tended to increase steadily in the following years(2015-2023).Conclusion Our data suggest that the BMD values vary among different populations,and future multi-center studies using more accurate BMD detection technology are warranted to capture the variation patterns of BMD with demographic characteristics of specific populations.

关 键 词：骨密度 骨质疏松 双能X射线吸收 流行病学 

分 类 号：R580[医药卫生—内分泌] R181.3[医药卫生—内科学]