果糖-1,6-二磷酸酶1在肿瘤发生发展中的作用及调控机制的研究进展  

Research progress Review on the role and regulatory mechanism of fructose⁃1,6⁃bisphosphatase 1 in tumors occurrence and development

作　　者：孙伯文 程媛[1] SUN Bo-wen;CHENG Yuan(Department of Obstetrics and Gynecology,Peking University People’s Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院妇产科,北京100044

出　　处：《解剖学报》2025年第2期248-251,共4页Acta Anatomica Sinica

基　　金：国家自然科学基金(82173119)。

摘　　要：在肿瘤的发生发展过程中,糖代谢关键酶果糖-1,6-二磷酸酶1(FBP1)起到了非常重要的作用。在多种类型肿瘤中,高表达FBP1基因预示患者预后良好。FBP1通过抑制糖酵解和脂代谢调控肿瘤细胞代谢重编程,通过调节NF-κB通路发挥蛋白磷酸酶的作用以及通过调节肿瘤免疫细胞浸润阻断肿瘤进展等作用。然而,在少部分肿瘤中,FBP1基因促进肿瘤恶性进展,其调控机制仍不明确,这有待后续的进一步研究。The metabolic enzyme fructose⁃1,6⁃bisphosphatase 1(FBP1)plays an important role in tumour development.In a variety of tumors,the high expression level of FBP1 has been correlated with a good prognosis.FBP1 can regulate the tumor cell metabolism reprograming by inhibiting glycolysis and fat metabolism,play the roles of protein phosphatase by regulating the NF⁃κB pathway and block tumor progression by regulating tumour immune cell infiltration.However,FBP1 promote malignant progression in a few tumors,some of the regulatory mechanisms are still unclear and need to be followed up with further research.

关 键 词：果糖-1 6-二磷酸酶1 肿瘤 代谢 发生发展 

分 类 号：R34[医药卫生—基础医学]