ADP-Hep-Induced Liquid Phase Condensation of TIFA-TRAF6 Activates ALPK1/TIFA-Dependent Innate Immune Responses  

作　　者：Liping Li Jia Wang Xincheng Zhong Yaoyao Jiang Gaofeng Pei Xikang Yang Kaixiang Zhang Siqi Shen Xue Jin Gaoge Sun Chaofei Su Shuzhen Chen Hang Yin 

机构地区：[1]State Key Laboratory of Membrane Biology,School of Pharmaceutical Sciences,Institute for Precision Medicine,Tsinghua-Peking Center for Life Sciences,Key Laboratory of Bioorganic Phosphorous chemistry and Chemical Biology(Ministry of Education),Tsinghua University,Beijing 100084,China [2]Department of Cancer Research,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China [3]State Key Laboratory of Membrane Biology,Institute of Molecular Medicine,College of Future Technology,Peking University,Beijing,China [4]School of Life Sciences,Tsinghua University,Beijing,100084,China

出　　处：《Research》2024年第4期205-221,共17页研究(英文)

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.21825702 and 22137004);Beijing Outstanding Young Scientist Program(Grant No.BJJWZYJH01201910003013);Tsinghua University Initiative Scientific Research Program of Precision Medicine(10001020105).

摘　　要：The ALPK1(alpha-kinase 1)-TIFA(TRAF-interacting protein with fork head-associated domain)-TRAF6 signaling pathway plays a pivotal role in regulating inflammatory processes,with TIFA and TRAF6 serving as key molecules in this cascade.Despite its significance,the functional mechanism of TIFA-TRAF6 remains incompletely understood.In this study,we unveil that TIFA undergoes liquid–liquid phase separation(LLPS)induced by ALPK1 in response to adenosine diphosphate(ADP)-β-D-manno-heptose(ADP-Hep)recognition.

关 键 词：PENDENT INCOMPLETE separation 

分 类 号：TG1[金属学及工艺—金属学]