Epigenetic Regulation of Ferroptosis in the Liver  

作　　者：Scott J.Dixon 

机构地区：[1]Department of Biology,Stanford University,Stanford,CA 94305,USA

出　　处：《Research》2024年第4期299-300,共2页研究(英文)

摘　　要：Ferroptosis is a non-apoptotic form of cell death defined by the iron-dependent accumulation of lipid peroxides[1].Iron is an essential redox-active metal that can be found at the active site of several enzymes.Iron can also be found in a pool of loosely coordinated or“labile”iron within the cytosol[2,3].Iron is thought to be necessary for ferroptosis by helping to catalyze the formation of reactive oxygen species(ROS),including lipid ROS,that promote the execution of ferroptosis[4].Both ironbinding enzymes and the labile iron pool likely contribute to the execution of ferroptosis,depending on circumstances[5].In mammals,complex homeostatic mechanisms ensure the appropriate amount of iron uptake necessary for survival while preventing the excess accumulation of iron that could be directly toxic or enhance ROS formation[6];disruption of systematic iron homeostasis is therefore presumed to have potent effects on ferroptosis sensitivity throughout the body.

关 键 词：COORDINATED EXCESS redox 

分 类 号：O64[理学—物理化学]