Pt–Se Hybrid Nanozymes with Potent Catalytic Activities to Scavenge ROS/RONS and Regulate Macrophage Polarization for Osteoarthritis Therapy  

作　　者：Hong Wei Hongjun Huang Haoqiang He Yuanming Xiao Lu Chun Zhiqiang Jin Hanyang Li Li Zheng Jinmin Zhao Zainen Qin 

机构地区：[1]Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration&Collaborative Innovation Center of Regenerative Medicine and MedicalBioResource Development and Application Coconstructed by the Province and Ministry,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China [2]Department of Orthopaedics,Affiliated Hospital of Guilin Medical University,Guilin 541000,China [3]Life Sciences Institute,Guangxi Medical University,Nanning 530021,China [4]Department of Orthopaedics Trauma and Hand Surgery,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China [5]School of Materials and Environment,Guangxi Minzu University,Nanning,Guangxi 53000,China [6]Guangxi Key Laboratory of Regenerative Medicine,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China

出　　处：《Research》2024年第4期365-380,共16页研究(英文)

基　　金：supported by the Guangxi Science and Technology Major Project(grant no.GuikeAA19254002);the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(grant no.2023GXNSFBA026291);the National Natural Science Foundation of China(grant nos.81972120 and 81960414).

摘　　要：The activation of pro-inflammatory M1-type macrophages by overexpression of reactive oxygen species(ROS)and reactive nitrogen species(RONS)in synovial membranes contributes to osteoarthritis(OA)progression and cartilage matrix degradation.Here,combing Pt and Se with potent catalytic activities,we developed a hybrid Pt–Se nanozymes as ROS and RONS scavengers to exert synergistic effects for OA therapy.As a result,Pt–Se nanozymes exhibited efficient scavenging effect on ROS and RONS levels,leading to repolarization of M1-type macrophages.Furthermore,the polarization of synovial macrophages to the M2 phenotype inhibited the expression of pro-inflammatory factors and salvaged mitochondrial function in arthritic chondrocytes.In vivo results also suggest that Pt–Se nanozymes effectively suppress the early progression of OA with an Osteoarthritis Research International Association score reduction of 68.21%and 82.66%for 4 and 8 weeks,respectively.In conclusion,this study provides a promising strategy to regulate inflammatory responses by macrophage repolarization processes for OA therapeutic.

关 键 词：Polarization CATALYTIC SYNERGISTIC 

分 类 号：O64[理学—物理化学]