全球过敏与哮喘欧洲网络严重过敏反应中心关于食物过敏管理中奥马珠单抗潜力的专家共识解读  

Interpretation of Global Allergy and Asthma European Network Anaphylaxis Centres of Reference and Exce-llence consensus statement: potential of Omalizumab in food allergy management

作　　者：韩鹏 柳杉杉 乔晶晶 申昆玲 Han Peng;Liu Shanshan;Qiao Jingjing;Shen Kunling(Department of Respiratory Diseases,Shenzhen Children's Hospital,Shenzhen 518038,China;Department of Respiratory Diseases,Bejing Children's Hospital,Capital Medical University,China National Clinical Research Center of Respiratory Diseases,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]深圳市儿童医院呼吸科,深圳518038 [2]国家儿童医学中心,国家呼吸系统疾病临床医学研究中心,首都医科大学附属北京儿童医院呼吸科,北京100045

出　　处：《中华实用儿科临床杂志》2025年第3期176-179,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：广东省高水平医院建设专项经费(2021-6)。

摘　　要：食物过敏患病率呈上升趋势, 可累及皮肤、呼吸、消化、心血管及神经等不同器官/系统, 严重者可出现致死性严重过敏反应。IgE介导的Ⅰ型超敏反应是食物过敏的常见类型, 也是导致严重过敏反应的主要机制。奥马珠单抗是首个获批用于IgE介导食物过敏治疗的生物制剂, 可作为食物过敏综合管理的一部分。由于缺乏某些关键的证据, 暂无法明确其在所有IgE介导食物过敏患者中的安全性和有效性。因此全球过敏和哮喘欧洲网络严重过敏反应中心组织专家针对奥马珠单抗的适用人群和治疗选择进行讨论, 并达成共识。现对其提出的共识内容进行解读, 以帮助临床医师更好地理解奥马珠单抗在IgE介导食物过敏患者中的应用。The incidence of food allergy is on the rise,with the capacity to impact various organ systems,including but not limited to the skin,respiratory system,gastrointestinal system,cardiovascular system,and nervous system.In extreme cases,these allergies can result in anaphylaxis.Immunoglobulin E(IgE)-mediated typeⅠhypersensitivity reactions are a common cause of food allergy and are the primary pathway to anaphylaxis.Omalizumab,the first biologic therapy approved for the treatment of IgE-mediated food allergy,can be incorporated into a comprehensive management strategy for food allergy sufferers.However,due to the lack of definitive evidence,the safety and efficacy of Omalizumab in all patients with IgE-mediated food allergy remain equivocal.In light of this,Global Allergy and Asthma European Network Anaphylaxis Centres of Reference and Excellence convened a panel of experts to deliberate on the appropriate patient and therapeutic strategies for Omalizumab,culminating in a consensus statement.This paper aimed to interpret the consensus proposed by the experts,with the objective of assisting clinicians in better understanding the application of Omazumab in patients with IgE-mediated food allergy.

关 键 词：食物过敏 免疫球蛋白E 严重过敏反应 奥马珠单抗 

分 类 号：R59[医药卫生—内科学]