利用无创、微创手段预测胆道闭锁Kasai肠吻合术后预后的研究现状  

Current status of research on the application of non-invasive or minimally invasive methods to predicting the prognosis of biliary atresia after Kasai portoenterostomy

作　　者：曾钦鹿 孙大燕 黄金狮[1,3] Zeng Qinlu;Sun Dayan;Huang Jinshi(Department of Neonatal Surgery,Jiangxi Provincial Children's Hospital,Nanchang 330006,China;Department of Medicine,Nanchang University,Nanchang 330006,China;Department of Neonatal Surgery,Bejing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]江西省儿童医院新生儿外科,南昌330006 [2]南昌大学医学部,南昌330006 [3]国家儿童医学中心,首都医科大学附属北京儿童医院新生儿外科,北京100045

出　　处：《中华实用儿科临床杂志》2025年第3期223-226,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金(82300574)。

摘　　要：胆道闭锁(BA)是一种严重的新生儿疾病, 本病受肝脏内外胆管的炎症和进行性纤维化的影响, 最终会进展为胆汁淤积性肝硬化。Kasai肠吻合术(KP)可帮助患儿重建胆汁引流通道, 是BA的主要管理策略。但肝内疾病的进展会使患儿在术后仍伴有门静脉高压、肝纤维化、终末期肝病等不同程度的并发症, 影响患儿短期和长期的预后及健康, 并可能在术后1年内进行肝移植治疗。目前临床上暂无可用于预测KP术后预后结果的共识策略, 仍需寻找一种非损伤性的、敏感度、特异度均较高的可靠手段来预测KP术后预后情况。最近, 有多项研究报道了关于预测KP术后预后的检查策略, 现按预测物来源分类对这些无创、微创方法进行综述。Biliary atresia(BA)is a serious neonatal disease,which can eventually develop into cholestatic cirrhosis due to inflammation and progressive fibrosis of bile ducts inside and outside the liver.Kasai portoenterostomy(KP)is the main management strategy of BA that can help children rebuild bile drainage channels.However,the progress of intrahepatic diseases will cause portal hypertension,liver fibrosis,end-stage liver disease and other complications to varying degrees after KP in children,affecting their short-term and long-term prognosis and health.It is also possible that children need liver transplantation within one year after operation.At present,there is no consensus strategy for the prediction of the prognosis of KP in clinical practice.There is a need to find a reliable non-invasive method with high sensitivity and specificity to predict the prognosis after KP.Recently,many examination strategies have been proposed for predicting the prognosis after KP.In this paper,these non-invasive or minimally invasive methods were reviewed according to the source of predictors.

关 键 词：胆道闭锁 生物标志 预后 

分 类 号：R65[医药卫生—外科学]