复方甲氧那明辅助治疗上呼吸道感染后咳嗽患者的临床疗效  

Clinical Efficacy of Compound Methoxyphenamine in the Adjuvant Treatment of Patients with Cough after Upper Respiratory Tract Infection

作　　者：林兵兵 徐红亮 龚俊 LIN Bing-bing;XU Hong-liang;GONG Jun(Department of Pharmacy,Kaifeng Central Hospital,Kaifeng 475000,China)

机构地区：[1]开封市中心医院药剂科,开封475000

出　　处：《四川解剖学杂志》2024年第6期41-43,共3页Sichuan Journal of Anatomy

摘　　要：目的:探讨复方甲氧那明对上呼吸道感染后咳嗽患者的辅助治疗效果.方法:选取2023年1月至2023年10月本院收治的80例因上呼吸道感染引发咳嗽症状的患者作为研究对象.根据治疗方案,将其分为观察组(n=44,采用复方甲氧那明治疗)和对照组(n=36,采用复方甘草片治疗).比较两组患者治疗后咳嗽程度[视觉模拟评分法(VAS)、中文版莱斯特咳嗽量表(LCQ-MC)],治疗效果,血清炎症因子[降钙素原(PCT)、白介素(IL)-6、肿瘤坏死因子(TNF)-α]水平及药物不良反应.结果:治疗后,观察组患者VAS评分低于对照组,LCQ-MC各维度评分高于对照组,差异均有统计学意义(P<0.05).治疗后,观察组患者治疗总有效率高于对照组,血清PCT、IL-6、TNF-α水平及药物不良反应总发生率均低于对照组,差异均有统计学意义(P<0.05).结论:上呼吸道感染后咳嗽患者接受复方甲氧那明辅助治疗的疗效较为显著,且安全性较高.Objective:To explore the adjuvant therapeutic effect of compound methoxyphenamine in patients with cough after clinical upper respiratory tract infection.Methods:A total of 80 patients with cough symptoms caused by upper respiratory tract infection admitted to our hospital from January to October 2023 were selected as research subjects.According to the treatment plan,they were divided into observation group(n=44,received compound methoxyphenamine)and control group(n=36,received compound licorice tablets).The degree of cough[visual analogue scale(VAS),Mandarin Chinese version of the Leicester cough questionnaire(LCQ-MC)],treatment effect,serum inflammatory factors[procalcitonin(PCT),interleukin(IL)-6,tumor necrosis factor(TNF)-α]level and adverse drug reactions were compared between the two groups.Results:After treatment,the VAS score of observation group was lower than that of control group,and the scores of LCQ-MC were higher than those of control group,and the differences were statistically significant(P<0.05).After treatment,the total effective rate of observation group was higher than that of control group,and the serum levels of PCT,IL-6,TNF-αand the total incidence of adverse drug reactions were lower than those in control group,and the differences were statistically significant(P<0.05).Conclusion:Compound methoxyphenamine is effective and safe in the adjuvant treatment of cough caused by upper respiratory tract infection.

关 键 词：复方甲氧那明 辅助治疗 上呼吸道感染 咳嗽 临床疗效 

分 类 号：R47[医药卫生—护理学]