重组人干扰素α2b联合布地奈德雾化吸入对新生儿肺炎患儿血气指标及炎症因子水平的影响  

Effects of Recombinant Human Interferonα2b Combined with Budesonide Aerosol Inhalation on Blood Gas Indexes and Inflammatory Factors in Neonates with Pneumonia

作　　者：马乐明 汪飞 马树峰 MA Le-ming;WANG Fei;MA Shu-feng(Department of Pediatrics,Taiqian County People's Hospital,Puyang 457600,China)

机构地区：[1]台前县人民医院儿科,濮阳457600

出　　处：《四川解剖学杂志》2024年第6期50-52,共3页Sichuan Journal of Anatomy

摘　　要：目的:探讨重组人干扰素α2b(RH-INFα2b)联合布地奈德雾化吸入对新生儿肺炎患儿血气指标及炎症因子水平的影响.方法:选取2022年1月至2024年1月本院收治的72例新生儿肺炎患儿作为研究对象.按照治疗方式,将其分为研究组(n=36,采用RH-INFα2b联系布地奈德雾化吸入治疗)和对照组(n=36,采用布地奈德雾化吸入治疗).比较两组患儿临床疗效、血气指标及炎症因子水平,并统计不良反应发生情况.结果:研究组患儿治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组患儿治疗后血氧分压(PaO_(2))、氧合指数水平均高于对照组,二氧化碳分压(PaCO_(2))水平低于对照组,差异均有统计学意义(P<0.05);研究组患儿治疗后白介素(IL)-6、超敏C反应蛋白(hs-CRP)、血清淀粉样蛋白A(SAA)水平均低于对照组,差异均有统计学意义(P<0.05);两组患儿不良反应总发生率比较,差异无统计学意义(P>0.05).结论:RH-INFα2b联合布地奈德雾化吸入治疗新生儿肺炎的效果较为显著,可有效改善血气指标,降低炎症因子水平,且安全性较高.Objective:To explore the effects of recombinant human interferon α2b(RH-INFα2b)combined with budesonide aerosol inhalation on blood gas indexes and inflammatory factors in neonates with pneumonia.Methods:A total of 72 children with neonatal pneumonia admitted to our hospital from January 2022 to January 2024 were selected as research subjects.According to treatment mode,they were divided into study group(n=36,treated with RH-INFα2b combined with budesonide aerosol inhalation)and control group(n=36,treated with budesonide aerosol inhalation).The clinical efficacy,blood gas index,inflammatory factor and occurrence of adverse reactions levels of the two groups were compared.Results:The total effective rate of study group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,the partial pressure of oxygen(PaO2)and oxygenation index of study group were higher than those of control group,and the pressure of carbon dioxide(PaCO_(2))level was lower than that of control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin(IL)-6,hypersensitive C-reactive protein(hs-CRP),serum amyloid A(SAA)in study group were lower than those in control group,and the differences were statistically significant(P<0.05).There was no difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:RH-INFα2b combined with budesonide atomization inhalation has a significant effect in the treatment of neonatal pneumonia,which can effectively improve the blood gas indexes and reduce the level of serum inflammatory factors,and has high clinical safety.

关 键 词：新生儿肺炎 重组人干扰素Α2B 雾化吸入 血气指标 炎症因子 

分 类 号：R72[医药卫生—儿科]